| Project
| Personnel
| January
| February
| March
| April
| May
| June
| July
| August
| September
| October
| November
| December
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| Chemical terms in GO. Phase I: metabolism, binding, transport
| Harold, David, Tanya, Jane, Chris, Becky, Paola
| Fix GO/goche misalignments - add CHEBI xps to GO
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| Chemical terms in GO. Phase II: improve enzyme functions, align with external databases inc. Rhea, MF-BP links for enzymes/metabolic processes
| Amelia, Chris, David, Jane, Tanya, Becky, Paola
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- Manual: Identify MF reaction terms that can't be expressed using has_input: CHEBI:XXX / has_output: CHEBI:XXX; manually research and review
- Automated: set up or augment script to produce has_input/has_output data for all rxns with RHEA xrefs (RHEA = EC rxns with CHEBI terms)
- Automated: create system to check GO rxns are up to date wrt RHEA, EC, MetaCyc data. Alert on clashes between sources.
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- Manual: continue review of non-conformant MF rxn terms
- Automated: continue development of system to check GO rxns are up to date wrt RHEA, EC, MetaCyc data. Look at incorporating KEGG and UM-BBD data (no bulk downloads available)
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- Manual: continue review of non-conformant MF rxn terms
- Automated: continue development of GO rxn update system.
- Automated: pull in MetaCyc pathway data - how to fit with GO BP?
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- Manual: continue review of non-conformant MF rxn terms
- Automated: look at other p'way databases (esp. those with BioPAX output) - fit with GO BP?
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- Manual: continue review of non-conformant MF rxn terms
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- Manual: continue review of non-conformant MF rxn terms
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| Chemical terms in GO. Phase III: biological roles
| Chris, David, Jane, Tanya, Becky, Paola
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| Cell ontology cross-products
| Paola, Chris, Jane, Alex
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| Review and improve biological_process_xp_cell
| Make TG templates
| Incorporate cell xps into GO
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| Internal Cross Products
| David, Tanya, Jane, Chris, Paola, Becky
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| Behaviour: GO/NBO integration
| Jane, Chris, George, Janna, David OS
| Survey ontology consumers to examine the implications of including non-GO ids in GO
| Generate file of mismatches between GO and NBO
| Fix GO (and NBO) so they align
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| Replace GO ids with equivalent NBO ids and definitions
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| Signaling overhaul
| Becky, Alex, Sandra, Peter, Ruth and others
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| Representing GPCR and second messenger signaling
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| Ligand-gated ion channels that signal
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| Define intracellular signaling start and stops
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| Ligand-mediated signaling pathways and receptor-mediated signaling pathways
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| Neurological processes and components
| Jane, Chris, David and Paola
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| Cardiac Conduction Ontology Development
| Ruth, Stan, Doug, David, Tanya, Becky, Paola and community experts
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| Apoptosis
| Emily, Becky, Paola, Pablo and community experts
| Revisiting second-level terms: feedback from experts
| Revisiting existing annotations to second-level terms
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| Final overall structure: sanity checks and completion
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| Write paper
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| Viral processes
| Jane, Philippe Le Mercier (SIB) and community experts
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