Annotation Extension Relation:activated by

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Definition

Identifies a chemical substance that increases the activity of the gene product.

Comment

This relation should not be used to annotate one gene product regulating another's activity; a regulator Molecular Function or regulation Biological Process should be used in such cases.

Synonyms

activated_by_chemical (EXACT)

activated_by_substance (EXACT)

activity_increased_by (EXACT)

Child terms

  • None.

Scope of use

Domain

GO:0003674 ! molecular_function

Range

CHEBI:24431 ! chemical entity

Annotation Extension Usage Examples

Specifying that a gene product is activated by a specific chemical

1. zinc activated ligand-gated ion channel (ZACN) is activated by Zn2+, PMID:12381728

So the annotation would be:

DB (Col 2) Object (Col 3) GO ID (Col 5) Reference (Col 6) Extension (Col 16)
Q401N2 ZACN GO:0048471 PMID:12381728 activated_by (ChEBI:29105, zinc ions)

Using examples to demonstrate Folding_and_Unfolding using the relationship activated_by

1. zinc activated ligand-gated ion channel (ZACN) is activated by Zn2+, PMID:12381728

Folded/unfolded DB (Col 2) Object (Col 3) GO ID (Col 5) Reference (Col 6) Extension (Col 16) Parent terms for new folded GO term
Unfolded Q401N2 ZACN GO:0048471 ligand-gated ion channel activity PMID:12381728 activated_by (ChEBI:29105, zinc ions)
Folded Q401N2 ZACN New GO term zinc-gated ion channel activity PMID:12381728 is_a GO:0048471 ligand-gated ion channel activity

OWL class expression: GO:0006509 ligand-gated ion channel activity AND activated_by SOME ChEBI:29105 zinc ions


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