Annotation Conf. Call 2017-10-24
From GO Wiki
- Manual annotation to uninformative high-level terms is strongly discouraged
- See: improving specificity by banning high level terms #1648
- For example: direct annotation to 'transport' (GO:0006810) is one case where a more specific annotation can likely be made
- In AmiGO, there are 53 experimentally supported annotations to 'transport'.
- Can groups check these annotations to see if a more granular term is appropriate?
- Annotations according to group:
(8) EcoCyc (7) EcoliWiki (7) MGI (7) PseudoCAP (6) SGD (5) UniProt (4) BHF-UCL (3) RGD (3) TAIR (2) GR (1) SynGO
- PomBase has a list of >1300 high-level terms that have a 'do not manually annotate' flag
- The proposal is to work through this list so annotations are consistent amongst all GOC members
- Transcription factor activity refactor
- Molecular Function terms describing 'transcription factors'
- See: Make parent term for transcription factor activity
- See: Transcription factor branch refactoring: overview of annotations of TFIIIC and TFIIB complexes
GOC Meetings Cambridge
- Review key action items from signaling workshop and GOC meeting
- GOC Cambridge 2017 Meeting Minutes
- Focus on annotation to signaling pathways
- Adoption of expanded set of BP relations
- Review use of contributes_to and colocalizes_with
- Noctua into full production mode
- Meetings on second and fourth Wednesdays at 8am PST to discuss issues
- Representation of protein complexes, and their constituent members, in GO and GO-CAM models
- Review HTP annotations
- On call: David H., Dmitry, Edith, Eric, George, Giulia, Harold, Jim, Karen, Kimberly, Li, Liz, Midori, Pascale, Paul T., Penelope, Petra, Robert, Rob N., Sabrina, Sage, Shur-Jen, Stacia, Stan, Suzi, Tanya, Terry, Val
- Action Item: Need curators to review experimental annotations to 'transport'
- Report back on any annotations that can't reasonably be transferred to a more granular term
- We will continue to look at the PomBase list and prioritize additional flags and error checks
- Will merge DNA binding transcription factor activity into nucleic acid binding transcription factor activity
- Goal: trying to more easily distinguish 'general' transcription factors (generally only described wrt pol II TFs) from specific, regulatory TFs
- Pascale will tag groups/people if annotations need review
- Pascale, Karen, Paul T. will discuss further
GOC Cambridge Meetings
- Will follow-up on signaling workshop with items using the go-annotation tracker
HTP Evidence Codes
- Helen will finish updating guidelines
- How doe the HTP evidence codes map up to existing GO evidence codes?
- They are in a separate branch, although still experimental.