Annotation Extension Relation:has regulation target

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Definition

Identifies a gene or gene product affected by a regulation Biological Process or regulator Molecular Function.

Comment

More details on the limited use of has_regulation_target with regulation of biological process annotations

Child terms

  • None

Scope of use

Domain

GO:0065007 ! biological regulation

Range

ENTITY_UNION:0000005 ! chemical, gene product or complex

Annotation Extension Usage Examples

Loss of transcription factor activity affects gene expression:

Statements from paper:

Indeed, LGG-1 was massively upregulated in atf-2(tm467) mutant embryos, as compared with the wild type (Fig. 6A). We observed a similar extent of BEC-1 upregulation in the atf-2-deficient background (data not shown).

Expressed in LEGO: http://go-genkisugi.rhcloud.com/seed/model/gomodel:taxon_6239-548253760000031


Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16)
WBGene00000220 atf-2(tm467) GO:0000122 negative regulation of transcription from RNA polymerase II promoter PMID:21502138 IMP has_regulation_target(WB:WBGene00000247 bec-1) 'pipe' has_regulation_target(WB:WBGene00002980 lgg-1

Using examples (from above) to demonstrate Folding_and_Unfolding using the relationship has_regulation_target

Specifying the gene which is a target of a transcription factor

gene transcription targets

Statement example:

Indeed, LGG-1 was massively upregulated in atf-2(tm467) mutant embryos, as compared with the wild type (Fig. 6A). We observed a similar extent of BEC-1 upregulation in the atf-2-deficient background (data not shown).

Folded/unfolded Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16) Parent terms of new folded GO term
Unfolded WBGene00000220 atf-2(tm467) GO:0000122 negative regulation of transcription from RNA polymerase II promoter PMID:21502138 IMP has_regulation_target(WB:WBGene00000247 bec-1)'pipe' has_regulation_target(WB:WBGene00002980 lgg-1
Folded WBGene00000220 atf-2(tm467) GO:0000122 negative regulation of transcription from RNA polymerase II promoter PMID:21502138 IMP No new GO term created

OWL class expression: GO:0000122 negative regulation of transcription from RNA polymerase II promoter AND has_regulation_target SOME WB:WBGene00000247 bec-1 OWL class expression: GO:0000122 negative regulation of transcription from RNA polymerase II promoter AND has_regulation_target SOME WB:WBGene00002980 lgg-1


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