Annotation Extension Relation:independent of

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Identifies an entity that was shown not to be required for the ontology term to apply to the annotated gene product.


not_dependent_on (EXACT)

==Child terms==

* None.

==Scope of use==


BFO:0000001 ! entity (Biological Process, Molecular Function, Cellular Component)


[[ENTITY_UNION:0000007]] ! chemical, gene product, complex, cellular component, biological process, molecular function, modification or sequence feature 


The GO editors have agreed that this relation should be deprecated.  There are two main reasons for this.

* The relation does not extend the meaning of the GO term, as annotation relations are meant to, but instead specifies conditions under which the annotation is true.  This can not be expressed in OWL.  Annotation extensions using this relation will never fold.
* The relation includes a hidden negation.  This is problematic for a number of reasons, the most important of which is that burying negations in otherwise positive relationships can cause serious problems for inference.

==Annotation Extension Usage Examples==

'''Specifying a protein's activity is not required for activation of transcription factor'''

Statement from paper;

''Protease-dead mutants of caspase-8 or -10, or PDCasp8 or PDCasp10, were equally potent in activating NF-kappaB, suggesting that the protease activity is not required and DED-containing prodomains are sufficient for NF-kappaB activation.''

{| class="wikitable" border="1"
! Gene Name (col 2)
! GO ID (col 5)
! Reference (col 6)
! Evidence (col 7)
! Annotation Extension (col 16)
| Q92851
| GO:0043123 <span style="color:green">positive regulation of I-kappaB kinase/NF-kappaB cascade</span>
| PMID:12884866
independent_of(GO:0008233 <span style="color:green">peptidase activity</span>)


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