Annotation Extension Relation:inhibited by

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Definition

Identifies a chemical substance that decreases the activity of the gene product.

Comment

This relation should not be used to annotate one gene product regulating another's activity; a regulator Molecular Function or regulation Biological Process should be used in such cases.

Synonyms

activity_decreased_by (EXACT)

inhibited_by_chemical (EXACT)

inhibited_by_substance (EXACT)

Child terms

  • None.

Scope of use

Domain

GO:0003674 ! molecular_function

Range

CHEBI:24431 ! chemical entity

Annotation Extension Usage Examples

Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) With (col 8) Annotation Extension (col 16)
P10869, HOM3 GO:0004072 aspartate kinase activity PMID:18626862 IDA inhibited_by: CHEBI:16857L-threonine
P32783, ABD1 GO:0004482, mRNA (guanine-N7-)-methyltransferase activity PMID: 7623811 IDA inhibited_by: CHEBI:16680 S-adenosyl-L-homocysteine

Using examples to demonstrate Folding_and_Unfolding using the relationship inhibited_by

Folded/unfolded Object (Col 2) GO ID (Col 5) Reference (Col 6) Evidence Extension (Col 16) Parent terms for new folded GO term
Unfolded P10869, HOM3 GO:0004072 aspartate kinase activity PMID:18626862 IDA inhibited_by: CHEBI:16857L-threonine
Folded P10869, HOM3 GO:0004072 aspartate kinase activity PMID:18626862 IDA No new GO term created

OWL class expression: GO: 0004072 aspartate kinase activity is inhibited_by SOME CHEBI: 16857 L-threonine


Folded/unfolded Object (Col 2) GO ID (Col 5) Reference (Col 6) Evidence Extension (Col 16) Parent terms for new folded GO term
Unfolded P32783, ABD1 GO:0004482, mRNA (guanine-N7-)-methyltransferase activity PMID: 7623811 IDA inhibited_by: CHEBI:16680 S-adenosyl-L-homocysteine
folded P32783, ABD1 GO:0004482, mRNA (guanine-N7-)-methyltransferase activity PMID: 7623811 IDA No new GO term created

OWL class expression: GO: 0004482, mRNA (guanine-N7-)-methyltransferase activity is inhibited_by SOME CHEBI:16680 S-adenosyl-L-homocysteine


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