Annotation Extension Relation:results in acquisition of features of

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Definition

The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity.

Child terms

  • None.

Scope of use

Domain

BFO:0000007 ! process (Biological Process or Molecular Function)

Range

ENTITY_UNION:0000006 ! entity

Annotation Extension Usage Examples

Enhancing Molecular Function and Biological Process Annotations

Specifying the cell or tissue type which acquires new features following a specific process or function

1. Differentiation of a particular cell type:

Statement from paper:

REN promoted neuronal differentiation of neural committed progenitor cells of CNS (ST14A cells, Fig. 7 A) or PNS (N2a cells, Fig. 7 B) origin.


Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16)
MGI:2448712 Ren GO:0030154 cell differentiation PMID:12186855 IDA results in acquisition of features of (CL:0000540 neuron)


2. A protein's involvement in changing a particular cell's shape:

Statement from paper:

Eotaxin, eotaxin-2, and MCP-4 were the most potent inducers of eosinophil shape change, followed by MCP-3, while MCP-1 and IL-8 were inactive. MCP-4 alone showed a bell-shaped eosinophil dose-response curve over the dose range tested. Eotaxin and eotaxin-2 were inactive on monocytes (Fig. 2⇓B), whereas MCP-1, -3, and -4 all induced monocyte shape change, with MCP-3 exhibiting the highest potency.

Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16)
Q99616 MCP4 GO:0008360 regulation of cell shape PMID:10072545 IDA results in acquisition of features of(CL:0000771 eosinophil) 'pipe' results in acquisition of features of(CL:0000576 monocyte)

Note the use of the pipe to create a multiple annotation extensions. The interpretation of this annotation is MCP4 is involved in the regulation of eosinophil cell shape and monocyte cell shape.

Using examples (from above) to demonstrate Folding_and_Unfolding using the relationship results_in_acquisition_of_features_of

Specifying the cell or tissue type which acquires new features following a specific process

1. Differentiation of a particular cell type:

Folded/unfolded Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16) Parent terms of new folded GO term
Unfolded MGI:2448712 Ren GO:0030154 cell differentiation PMID:12186855 IDA results_in_acquisition_of_features_of(CL:0000540 neuron)
Folded MGI:2448712 Ren New GO ID neuron cell differentiation PMID:12186855 IDA is_a GO:0030154 cell differentiation

OWL class expression: GO:0005515 cell differentiation results_in_acquisition_of_features_of SOME CL:0000540 neuron

2. A protein's involvement in changing a particular cell's shape:

Note the use of the pipe to create a multiple annotation extensions.

Folded/unfolded Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16) Parent terms of new folded GO term
Unfolded Q99616 MCP4 GO:0008360 regulation of cell shape PMID:10072545 IDA results_in_acquisition_of_features_of(CL:0000771 eosinophil) 'pipe' occurs_in(CL:0000576 monocyte)
Folded Q99616 MCP4 New GO ID regulation of eosinophil cell shape PMID:10072545 IDA is_a GO:0008360 regulation of cell shape
Folded Q99616 MCP4 New GO ID regulation of monocyte cell shape PMID:10072545 IDA is_a GO:0008360 regulation of cell shape

OWL class expression: GO:0008360 regulation of cell shape results_in_acquisition_of_features_of SOME CL:0000771 eosinophil AND occurs_in SOME CL:0000576 monocyte


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