Annotation Extension Relation:results in morphogenesis of

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Definition

The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state.

Identifies the cell, tissue, or anatomical entity which are under going the morphogenic process.

Child terms

  • None.

Scope of use

Domain

BFO:0000007 ! process (Biological Process or Molecular Function)

Range

ENTITY_UNION:0000006 ! entity

Annotation Extension Usage Examples

Enhancing Molecular Function and Biological Process Annotations

Specifying the cell or tissue type which are under going the morphogenic process

1. A protein's involvement in changing a particular cell's shape:

Statement from paper:

Eotaxin, eotaxin-2, and MCP-4 were the most potent inducers of eosinophil shape change, followed by MCP-3, while MCP-1 and IL-8 were inactive. MCP-4 alone showed a bell-shaped eosinophil dose-response curve over the dose range tested. Eotaxin and eotaxin-2 were inactive on monocytes (Fig. 2⇓B), whereas MCP-1, -3, and -4 all induced monocyte shape change, with MCP-3 exhibiting the highest potency.

Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16)
Q99616 MCP4 GO:0008360 regulation of cell shape PMID:10072545 IDA results_in_morphogenesis_of(CL:0000771 eosinophil) 'pipe' results_in_morphogenesis_of(CL:0000576 monocyte)

Note the use of the pipe to create a multiple annotation extensions. The interpretation of this annotation is MCP4 is involved in the regulation of eosinophil cell shape and monocyte cell shape.

More examples of this usage of occurs_in can be found on the documentation page for Column_16:_Cell_Type

Using examples (from above) to demonstrate Folding_and_Unfolding using the relationship results_in_morphogenesis_of

1. A protein's involvement in changing a particular cell's shape:

Note the use of the pipe to create a multiple annotation extensions.

Folded/unfolded Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16) Parent terms of new folded GO term
Unfolded Q99616 MCP4 GO:0008360 regulation of cell shape PMID:10072545 IDA results_in_morphogenesis_of(CL:0000771 eosinophil) 'pipe' results_in_morphogenesis_of(CL:0000576 monocyte)
Folded Q99616 MCP4 New GO ID regulation of eosinophil cell shape PMID:10072545 IDA is_a regulation of cell shape
Folded Q99616 MCP4 New GO ID regulation of monocyte cell shape PMID:10072545 IDA is_a regulation of cell shape

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