Annotation Extension field: Supplying temporal location information to a GO annotation

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Specifying the stage at which a localization is observed

Cellular component annotations can be enhanced by specifying that localization is observed during a cell cycle or developmental stage, or in the context of a specific biological process.

If a gene product is localized to the nuclear periphery in S phase, G2, and mitosis (S. pombe Ulp1; PMID:11884512):

 col 5: GO:0034399 ! nuclear periphery
 col 16: exists_during(GO:0000084)|exists_during(GO:0000085)|exists_during(GO:0007067) ! S phase of mitotic cell cycle,
 G2 phase of mitotic cell cycle, and mitosis respectively

If a gene product is localized to the spindle pole body (SPB) and nucleolus in interphase and to the actin contractile ring, the mitotic spindle, and kinetochores during mitosis (S. pombe Clp1; PMID:16085490):

 col 5: GO:0005816 ! spindle pole body
 col 16: exists_during(GO:0051329) ! interphase of mitotic cell cycle
 col 5: GO:0005730 ! nucleolus
 col 16: exists_during(GO:0051329) ! interphase of mitotic cell cycle
 col5: GO:0005826 ! actomyosin contractile ring
 col 16: exists_during(GO:0007067) ! mitosis
 col5: GO:0005819 ! spindle
 col 16: exists_during(GO:0007067) ! mitosis
 col5: GO:0000777 ! condensed chromosome kinetochore
 col 16: exists_during(GO:0007067) ! mitosis

Note that an experiment that supports 'CC exists_during BP' may also support an annotation of the 'BP occurs_in CC' pattern.

Also see the go-discuss mailing list for more information.