CAMP-mediated signaling ; GO:0019933

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cAMP SIGNALING OVERVIEW

  • liganded-GPCRs signal through G-proteins to either ACTIVATE or INACTIVATE adenylate cyclase (AC)
  • Activated adenylate cyclase produces cAMP from ATP
  • cAMP goes on to activate e.g. PKA.

For an image, see http://www.springerimages.com/Images/RSS/1-10.1007_s00441-006-0226-0-4

outstanding questions

  • Where does cAMP signaling start?
    • With AC activity?
    • Upstream with any signal or signal transducer that signals THROUGH cAMP?
  • Does cAMP signaling include signaling both as a result of an INCREASE or a DECREASE in cAMP?


GO TERMS

  • cAMP-mediated signaling ; GO:0019933
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway ; GO:0007188
  • adenylate cyclase activity ; GO:0004016


SF ITEMS