FlyBase 2014-Mar 3 to June 5

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Staff

[please include FTEs working on GOC tasks designating as well how many FTEs funding by GOC NIHGRI grant]

GO Curators: (Total ~1.5 FTE) Susan Tweedie (0.8 FTE)* Helen Attrill (~0.2 FTE) Gillian Millburn (~0.1 FTE) Pete McQuilton (~0.1 FTE) Steven Marygold (~0.1 FTE) Raymund Stefancsik (~0.1 FTE) Laura Ponting (~0.1 FTE)

Developers: (Total ~0.05 FTE) Andy Schroeder (~0.025) Kathleen Falls (~0.025)

NO FTE are funded by the GOC

  • Funded by MRC grant. All other staff are funded by FlyBase NIHGRI grant (HG000739)

Annotation Progress

Between 20140303- 20140612 5036 manual GO annotations were made for Drosophila melanogaster gene products.

Based on the latest public FlyBase release FB2014_03 (May 9th May)

Total no. of GO annotations 91620 Total no. of GO cellular component annotations 21013

Total no. of GO molecular function annotations 26617

Total no. of GO biological process annotations 43990

No. of GO annotations assigned to targets manually 78843

No. of GO annotations assigned to targets automatically 12777

No. of gene targets (RNA or protein coding genes) 17083 No. of genes with one of more GO terms 11850

No. of genes are annotated with root terms only 998

No. of genes with at least one GO term from each GO aspect 8113

No. of genes with at least one non-root GO term from any GO aspect 10852

No. of genes with at least one non-root GO term from all three GO aspects 6085

No. of genes with at least one non-root GO cellular component term 7736

No. of genes with at least one non-root GO molecular function term 8963 No. of genes with at least one non-root GO biological process term 9364

No. of genes with at least one GO term based on experimental evidence 5889

No. of genes with at least one GO term based on experimental evidence for all three GO aspects 1554

Methods and strategies for annotation

(please note % effort on literature curation vs. computational annotation methods) a. Literature curation: (99% effort)

b. Computational annotation strategies: (1% effort) Annotations based on InterPro to GO mappings

c. Priorities for annotation Genes that currently lack GO annotation Genes that are missing GO annotation for one or more aspect Genes that are homologs of human disease genes Ensuring consistent GO annotations for gene families

Presentations and Publications

a. Papers with substantial GO content NONE

b. Presentations including Talks and Tutorials and Teaching NONE

c. Poster presentations NONE