Guidelines for new Binding terms
From GO Wiki
Guidelines for protein binding (GO:0005515 & children)
- Annotation guidelines state that GO:0005515 protein binding should be captured with
- IPI evidence
- a protein ID in the
withfield, which represent the target protein with which the experiment was done (mandatory)
- Ideally, a protein ID in the
has inputextension field, which corresponds to the entry of the actual physiological target (ie human to human interaction should have two human proteins, (1) the enabler, (2) the input, and if the experiment was done with a mouse protein, that mouse protein ID should be captured in the
with, and the orthologous human protein in the
has inputextension field.
- The exception to this practice include terms such as actin binding / tubulin binding / histone binding. The reason for those exception in that many species have many identical copies and it isn't often clear which copy of "actin" was used, and so it is difficult to specify in the with field.