Introduction to Annotation

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 This is also on the GO website:
 Maybe we should just link to it ? 

Semantics of a GO Annotation

  • GO annotations are associations between a gene or gene product and a GO term, supported by evidence and a reference.
  • GO annotations represent the normal, in vivo biological role of genes or gene products.
  • GO terms belong to one of three aspects: Molecular Function (MF), Cellular Component (CC), and Biological Process (BP).
  • Association with a gene or gene product product to a term from these ontologies is a statement that means:
    • Molecular Function: the molecular activities of gene products
    • Cellular Component: where gene products are active
    • Biological Process: pathways and larger processes made up of the activities of molecular multiple gene products

General Principles of GO Annotation

  • A gene product can be annotated to zero or more terms from each ontology.
  • Gene products are annotated to the most detailed (i.e. granular) level in the ontology that is supported by the experimental evidence in the cited reference.
  • Annotation to a GO term implies annotation to its parents.
  • GO annotations are meant to reflect the most up-to-date view of a gene product's role in biology.
  • Because biological knowledge changes, annotations for a given gene product may change to reflect changes in knowledge and/or changes in the ontology.

Old wiki pages to review

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