LEGO April 6 2015
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Agenda
- Thermosensory Pathway in C. elegans
- Initial entry point for LEGO: sensation of temperature change and signaling pathway to transmit this information
- Upstream: cell fate acquisition of neurons involved
- Upstream: assembly and organization of subcellular structures (e.g. cilium, microvilli) that mediated sensory perception
- Downstream: how perception of stimulus and subsequent signaling leads to change in cellular and organismal behavior, e.g. increased transcription of specific mRNAs or taxis, respectively
- Also, review Phenotype2GO-based annotations, as well as Anatomy Term functions, in WB to see how they map onto the LEGO model
- Also, review ontology for coverage of specific steps in overall process
- Sensation of temperature change and signaling pathway
- detection of temperature stimulus involved in thermoception
- not known, possibly a G protein-coupled receptor; possibly a link to changes in lipid behavior
- receptor guanylyl cyclase signaling pathway
- A number of gene products known:
- receptor guanylyl cyclases: gcy-8, gcy-18, gcy-18
- cGMP-gated channels: tax-2, tax-4, cng-3
- A number of gene products known:
- detection of temperature stimulus involved in thermoception
- Some references:
- Molecular biology of thermosensory transduction in C. elegans.
- Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase.
- Co-expression of the transcription factors CEH-14 and TTX-1 regulates AFD neuron-specific genes gcy-8 and gcy-18 in C. elegans.
- Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron.