LIG4

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Information and Links

LIG4 ligase IV, DNA, ATP-dependent

Also known as: Lig4, Lig4_predicted, DNA ligase IV, ligase IV, tiny

Nomenclature accurate as of December 6, 2007

Gene Details: HGNC (human) MGI (mouse) RGD (rat)

Entrez Gene Pages: Human Mouse Rat Cow


Orthology Predictions

Through MGI (human and other mammalian species)

Through HGNC/HCOP (vertebrate and invertebrate orthologs)


Existing GO Annotation

Use the links below as well as the links to the gene information pages above to check existing GO annotation for LIG4.

GO annotation for a particular gene in a set of orthologous genes will vary between species depending upon the experimental evidence available, annotation completeness, and fundamental differences in biology. Please take note of any aspects of the gene's biology that are not represented in the existing GO annotations.


Gene Ontology Consortium Amigo Browser: Many Species

GOA QuickGO Browser: Human Mouse

MGI Browser: Mouse Mouse-Human-Rat Comparative GO Graph

RGD Browser: Rat


Community Input Section

Examine the GO annotations for LIG4, using the links above, and tell us about aspects of its biology that are still unannotated by editing the wiki page directly. GO curators are notified when particular gene pages are changed and will act upon your contributed information to create new GO annotations.

Supporting literature may be found through the GeneRIFs on the Entrez Gene pages above, or directly through PubMed or CiteXplore


Please duplicate and complete the following sections:

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Gene function, process, cellular location or interacting partner (as a list or short summary):
From the abstract "DNA ligase IV (LigIV) deficiency was identified as the molecular basis for a severe form of combined immunodeficiency in two microcephalic siblings with cellular radiosensitivity. In one patient the diagnosis was made directly after birth, allowing analysis of the role of LigIV in the development of specific immune cells. Absolute numbers of B cells were reduced 100-fold and alphabeta T cells 10-fold, whereas gammadelta T cells were normal. Spectratyping of all three cell populations showed a diverse repertoire, but sequencing of IgH V(D)J junctions revealed shorter CDR3 regions due to more extensive nucleotide deletions among D and J elements and fewer N nucleotide insertions."

V(D)J recombination
B cell differentiation
T cell differentiation

Method or evidence used to support the annotation (eg enzyme assay, flow cytometry, immunoprecipitation, mutant phenotype, etc.):

Supporting Literature Reference (PubMedID or citation): PMID:16585603

Contact email address (optional): adiehl@informatics.jax.org

Additional notes: GOA should work on this reference.

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Gene function, process, cellular location or interacting partner (as a list or short summary):

Method or evidence used to support the annotation (eg enzyme assay, flow cytometry, immunoprecipitation, mutant phenotype, etc.):

Supporting Literature Reference (PubMedID or citation):

Contact email address (optional):

Additional notes:

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Thank you


Link to example of submitted GO annotation



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