Ontology Editing Examples

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Regulation of a pathway by regulation of enzyme activity

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Create terms as follows:

hydroxymethylglutaryl-CoA reductase (NADPH) activity ; GO:0004420 (EC:1.1.1.34)
--[isa]hydroxymethylglutaryl-CoA reductase (NADPH) activity involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway ; GO:NEW1
--[neg_reg]negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity ; GO:NEW2
----[isa]negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway by negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity ; GO:NEW4
isopentenyl diphosphate biosynthetic process, mevalonate pathway ; GO:0019287 (PWY-922)
--[partof]hydroxymethylglutaryl-CoA reductase (NADPH) activity involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway ; GO:NEW1
----[neg_reg]negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway by negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity ; GO:NEW4
--[neg_reg]negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway  ; GO:NEW3
----[isa]negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway by negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity ; GO:NEW4


Relevant SourceForge Items

https://sourceforge.net/tracker/?func=detail&aid=3436056&group_id=36855&atid=440764