Beta-catenin interacting protein family Since this family is so small and has so few annotations, I am posting the entire evidence file (minus boilerplate) instead of just questions. -Mike
Description of phylogeny
This is a very small family with two paralogous vertebrate clades, one of beta-catenin interacting protein (Ctnnbip1), and one with Lzic (Leucine zipper and ICAT homologous domain-containing protein). Ctnnbip1 has one known molecular function: binding beta-catenin (from mouse); Lzic has one known molecular function: NOT binding beta-catenin (from zebrafish). There are several BP annotations for Ctnnbip1, but otherwise nothing else is annotated in GO.
Since the only thing we really know about Lzic is that it doesn't bind beta catenin, I will treat the Ctnnbip1 clade as the entire family and AN4 as the root.
Note: As of today, 19 Aug 2010, there are several annotations for human CTNNBIP1 in QuickGO that are not shown in PAINT. They are from as far back as 20100722.
-As stated above, the only thing we know is that mouse Ctnnbip1 binds beta catenin. Propagate "beta-catenin binding" to AN4.
-There are no CC annotations for this family.
-Since only one protein, mouse Ctnnbip1, is annotated, propagate the following non-redundant terms to AN4: GO:0001658 branching involved in ureteric bud morphogenesis GO:0009952 anterior/posterior pattern formation GO:0048662 negative regulation of smooth muscle cell proliferation GO:0030178 negative regulation of Wnt receptor signaling pathway GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
-Do not propagate the following terms where the effect is indirect or the meaning is covered by the above: GO:0043433 negative regulation of transcription factor activity GO:0043392 negative regulation of DNA binding
Notes for MOD curators
-Mouse: There are 2 TAS annotations from PMID 10898789 ("nucleus" and "cytoplasm").
-Curator Response: TAS annotations will be removed when experimental annotation exists.
MSL 19 August 2010