Panther ID:14218

TPP1(CLN2) family

Source forge tracker

https://sourceforge.net/tracker/?func=detail&aid=1953759&group_id=36855&atid=1040173

• Doug noted that the human gene was incorrectly annotated to 'aminopeptidase activity' (corrected)
• also, dicty had an annotation to 'subtilase activity' from Interpro which has now been replaced by 'serine-type endopeptidase activity' (GO:0004252)

http://www.ebi.ac.uk/interpro/IEntry?ac=IPR000209

• those should probably be IEAs

Annotations to propagate

• Only human and mouse have EXP annotations
• Nothing can be propagated to other species based on the annotations we have.

• Annotations:

• • tripeptidyl-peptidase activity (GO:0008240) - ISS with human (UniProtKB:O14773), rat (RGD:621296)
  • proteolysis (GO:0006508) ISS with human (UniProtKB:O14773), rat (RGD:621296)
  • ? peptide catabolic process (GO:0043171) ISS with human (UniProtKB:O14773)
  • lysosome (GO:0005764) ISS with mouse ISS with human (UniProtKB:O14773)
  • lysosome organization (GO:0007040) (MGI:3693379|UniProtKB:O14773)

• • ? nervous system development (GO:0007399) : human only
  • ? neuromuscular process controlling balance : mouse only
  • -> neurological system process (GO:0050905) suggested parent (oups - not a parent of nervous system development). But one wants to say something about the nervous system??

NOT to propagate:

• Soluble fraction (GO:0005625) - mouse and rat have ISS/ISO to human
• Mitochondrion (GO:0005739): mouse HTP data. Human and rat have ISS/ISO to mouse
• Peptide binding (GO:0042277) - Human have ISS to rat
• protein binding (GO:0005515) - mouse and rat have ISS to human
• bone resorption (GO:0045453) - Human and rat have ISS/ISO to mouse
• neuromuscular process controlling balance (GO:0050885) - Human and rat have ISS/ISO to mouse

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