Panther ID:22573

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HPRT1, hypoxanthine guanine phosphoribosyltransferase

Summary

There are several Molecular Function annotations to propagate, mostly to phosphoglucomutase activity (GO:0004614). This family also enables propagation of a NOT annotation (see 4) below). I was unable to generate a GAF file because in one case, I need to propagate with a parent term (see 2) below), which cannot be done via the current version of PAINT.


Cross references: See SourceForge items 1893061 and 1893082.

Molecular Function: DONE

Propagation:

1) phosphoglucomutase activity (GO:0004614)

Up-propagation to common ancestor node AN100, down-propagation to the following Ref Genome proteins:

HUMAN_ENSG00000165434

MOUSE_MGI:1918224

RAT_1584532

RAT_1583226

CHICK_419052

DANRE_ZDB-GENE-041008-205

HUMAN_ENSG00000169299

SCHPO_SPCC1840.05c

CAEEL_WBGene00012803

DANRE_ZDB-GENE-040426-2218

CHICK_776748

CHICK_42635

RAT_1306061

because of positive experimental annotations to MOUSE_MGI:97564, YEAST_S0000004891 (PGM3), ECOLI_PHOSPHGLUCMU-MONOMER

2) phosphoglucomutase activity (GO:0004614)

Up-propagation to common ancestor node AN2, down-propagation to the following Ref Genome proteins. Note that the AN9 node is the NOT clade, and positive propagation to that node should not be done:

RAT_3316

CHICK_424691

DANRE_ZDB-GENE-040426-1245

CAEEL_WBGene00019890

DICDI_DDB_G0288483

SCHPO_SPBC32F12.10

ARATH_LOCUS NP_173732

ARATH_LOCUS NP_177230

because of positive experimental annotations to:

HUMAN_ENSG00000079739

MOUSE_MGI:97565

DROME_FBgn0003076

YEAST_S000004711

YEAST_S000001610

ARATH_LOCUS NP_199995

3) intramolecular transferase activity, phsophotransferases (GO:0016868)

Note that this is a parent term to the child terms used in the direct, experimental annotations.

Up-propagation to common ancestor node AN318, down-propagation to the following Ref Genome proteins:

RAT_1305221

CHICK_421841

DANRE_ZDB-GENE-041024-13

CAEEL_WBGene00009006

DROME_FBgn0036298

SCHPO_SPAC13C5.05C

SCHPO_SPAC1296.01C

ARATH_LOCUS NP_568359

DICDI_DDB_G0281789

ARATH_LOCUS NP_177239

ARATH_LOCUS NP_568350

ECOLI_PHOSMANMUT-MONOMER P24175

because of positive annotations to HUMAN_ENSG00000013375, MOUSE_MGI:97566, YEAST_S000000784 PCM1, ECOLI_PHOSGLUCOSAMINEMUT-MONOMER P31120.

4) hypoxanthine phosphoribosyltransferase activity (GO:0004422)

Up-propagation to AN204, down-propagation to the following Ref Genome proteins:

Arabidopsis NP_177320

Dicty DDB_G0285193

WBGene00013690

ZDB-GENE-040426-1918

ZDB-GENE-040625-17

ENSG00000099256

Rat Prtfdc1 (RGDID 1310177)

Chicken XP_418601

ZDB-GENE-980526-324

Chick XP_001235912

Chick Q9W719

because of positive experimental annotations to HUMAN_ENSG00000165704, MOUSE_MGI:96217, RAT_2826, ECOLI_HYPOXANPRIBOSYLTRAN-MONOMER P0A9M2.

5) ===== phosphoacetylglucosamine mutase activity (GO:0004610) =====

Up-propagation to AN321, down-propagation to the following Ref Genome proteins:

RAT_1305221

CHICK_421841

DANRE_ZDB-GENE-041024-13

CAEEL_WBGENE00009006

DROME_FBGN0036298

SCHPO_SPAC13C5.05C

SCHPO_SPAC1296.01C

ARATH_LOCUS NP_568359

because of positive experimental annotations to HUMAN_ENSG0000001375, MOUSE_MGI:97566, YEAST_S000000784 PCM1.


6) NOT phosphoglucomutase activity (GO:0004614) to the PGM5 clade.

Up-propagation to AN9, down-propagation to the following Ref Genome proteins:

HUMAN_ENSG000000204794

RAT_1584213

RAT_1307969

CHICK_427215

DANRE_ENSDARG000000060745

Notes: mouse and human had experimental (IDA) annotations to NOT, but based on protein alignments, can extend the propagation because the active sites have been well characterized. Thus, the alignment of active sites makes the NOT vs. the positive annotations clear. See File:GO EUGENE 2009 pipeline1.ppt for details. Just a note about one protein that has a wildtype site for one active site but mutated for the others: XENTR_ENSXETG000000001670 is in this clade but has the "active" active site at about residue 675 TASHN (where the NOTs have TASHC or TASHS). But, this protein has the other mutated active sites (~1100 FDAD, while active sites have FDGD, and ~1325 has FDY while active sites have YDY).

Biological Process: No propagation

Cellular Component: No propagation


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