Priority Cardiovascular genes
From GO Public
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[edit] Useful links
Return to Cardiovascular Main Page
RGD has completed a Cardiovascular Disease Portal initiative in which genes associated with cardiovascular diseases, related phenotypes, biological processes and relevant pathways were prioritized for full curation including comprehensive GO annotation. This provides a great starting point for others who wish to do similar initiatives. [1]
Full list of cardiovascular associated genes: Cardiovascular Associated Genes
[edit] Annotation Priority Genes
The annotation priority genes will be 'comprehensively' annotated by GO annotators, however the complete accumulated knowledge about these genes may not be fully encapsulated by these annotations. For some genes the volume of literature is too great for 'comprehensive' annotation within a few days, these genes are therefore given a 'first pass' status. The list of the first 247 prioritized genes is available at the bottom of this page.
[edit] How to contribute information to GO annotators
Where a wiki gene page is available please use the community annotation section to suggest further biological process, molecular function or cellular component terms or phrases which are missing from the annotated protein record, see Background and Instructions for more information.
Alternatively suggestions can be made using the GOA User Survey or by email to goannotation@ucl.ac.uk
[edit] Annotation Progress
The following genes have been either 'comprehensively' annotated (but not necessarily complete) or have had 'first pass' annotation.
[edit] Comprehensively Annotated
The gene symbols in blue are linked to gene-specific wiki pages, those in red do not have wiki pages created yet, but some do have links to the QuickGO browser view of the current GO annotation of the human gene (numbered in blue brackets).
[edit] First Pass Annotation Only
For genes with only 'first pass' annotation, the literature available, and the diversity of functions for the gene, is too great, to allow 'comprehensive annotation' at this stage in the project. We would therefore be particularly grateful for suggestions to improve the annotation of these genes.
| PDGFA | PDGFRA | PPARG | SORT1[24] | TNF |
[edit] Target Genes for May 2008
| ACE | ACE2 | AGTR1 | AGTR2 | BBS1 | BBS2 | BBS4 | BBS5 |
| BMP10 | BMPR2 | CAV3 | HIF1A | HMOX1 | IGF1 | INS | INSR |
| LBP | NOG | NOS1 | NOS2A | NOS3 | NRG1 | PPARG | RARA |
| RARG | RBP4 | RXRA | SIRT1 | SOD2 | SOX4 | SRF | TGFB2 |
| TGFBR2 | TGFBR3 | TNNC1 | USF1 | VCAM1 | VEGFA | VNN1 | WFS1 |
[edit] The first 247 cardiovascular-associated genes to be annotated as a priority
The gene symbols in red do not have wiki pages created yet.
[edit] Community Input Section
Please use the area below to list genes you think should be added to the list on this page. Thank you.
GATA3, GATA4, GATA6, NKX2.5, TBX5 K+ channel genes
SCL30A8, TCF7L2, IDE-KIF11-HHEX cluster, EXt2-ALX4 cluster, CDKN2A, CDKN2B, CDKAL1, IGF2BP2, FTO, KNCJ11
CD47
TSP1
