Protein and peptidyl amino acid modification / protein processing
The protein amino acid modification and peptidyl amino acid modification terms need to be be revisited and revised. Some of the issues:
- The difference between peptidyl and protein needs to be cleared up.
- There is currently no link between 'peptidyl-amino acid modification ; GO:0018193' and the individual types of modification (protein amino acid acylation, protein amino acid deamination etc etc).
- The difference between protein amino acid modification and protein modification needs to be decided and made clear in the term definitions. E.g. 'protein palmitoleylation ;GO:0045234' vs 'protein amino acid palmitoleylation ; GO:0045235' DONE- terms merged
- There is currently no generic term for C-terminal protein amino acid modification (the N-terminal equivalent does exist: GO:0031365).
The protein modification terms are currently divided into 4 sections:
- Type of modification (eg phosphorylation, acylation etc)
- WHICH amino acid is modified (peptidyl-tyrosine modification)
- WHERE in the protein the modified amino acid lies (N-terminal protein amino acid modification ; GO:0031365)
- WHEN the modification occurs (in cases where we know): post translational vs co-translational
Specific changes to do:
- N-terminal protein amino acid modification ; GO:0031365 probably needs to be moved out from being a child of peptidyl-amino acid modification ; GO:0018193
PROTEIN PROCESSING also needs to be looked at:
At the moment, it's a child of protein maturation, and its definition is restricted to cleavage.Is this too restrictive?
Related SF items