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- Includes both the signaling pathway AND the downstream cellular process (e.g. transcription).
- Note that ligand are included in the response.
- Begins with an active signal. Includes transport of the active signal from the signaling to the receiving cell AND signal transduction in the receiving cell.
- Excludes synthesis of the signal (e.g. translation, or processing to form an active signal); these events are upstream of (and regulate) signaling.
- Limited to events IN THE RECEIVING CELL. Begins with receptor-ligand interaction (E.g. binding) and ends with REGULATION of a downstream cellular process.
- Note that ligands are included in signal transduction. Ligands are signals and are not signal transducers.
- Specific instances of signal transduction, named after the receptor or the ligand (or both).
- Specific transcription factors are INCLUDED in the signaling pathway because they REGULATE transcription.
- RNA polymerase and other basal transcription factors are NOT included in the signaling pathway because they are involved in transcription itself.
INTRACELLULAR SIGNAL TRANSDUCTION
- Any signaling in the intracellular region of the SIGNAL RECEIVING CELL.
- Includes intracellular domains of a receptor signaling to downstream intracellular components.
- Includes signaling cascades
- A group of INTRACELLULAR signal transducers where the signal is amplified
- NB: Used to be used to refer to any intracellular signaling cassette/module, but this didn't reflect its use in the community, so was updated so that it's only used when a signal is amplified.