Talk:2010 GO-camp Response to terms issues
From GO Wiki
Minutes from phone meeting 22 April 2010
- Example: response to small molecule - aren't these just signalling?
- how do distinguish between response to and e.g. signalling
- Becky: signalling and response terms are linked
- not always - e.g. for some stress terms
- Becky: signalling ends when the response begins e.g. includes the transcription, but not the downstream bits effects of the proteins
- When it comes to big screens - should we even annotate?
- IEPs - how to correctly annotate to response to terms
- Are we going to keep IEPs for response to? Or are we interested in just annotating direct responses?
- Ruth: we need specific examples of the responses as child terms
- Example: insulin signalling/insertion of glucose transporter into the membrane are currently not linked. Need a term response to insulin to group these two processes.
- Pascale: response to terms are hacks to capture the experiments?
- Ruth: these are useful, allow us to group terms together as part of a response.
- Val: where would stress response go without response to stress?
- Jane: Where does the response end? Could potentially be indefinite e.g. where a whole organism responds to something.
- Val: stress résponse is a valid set of processes whose transcription is induced by multiple stresses.
How to proceed?
- Inconsistencies in the way response to is used.
- Definitions need improving - further annotation documentation also needed.
- Could we take a set of existing annotations and see whether specific child terms could be made for better annotation
- Need examples of papers where you might annotate to response to terms
- Pascale to collect annotation examples and post on the wiki.