17 March 2015 PAINT Conference Call

PAINT conference call minutes, March 17rd, 2015

Participants:

Agenda

• Family presentation (Huaiyu) - PTHR11437
  • It is an RNase A family (EC 3.1.27.5)
  • MF
    • The first enzyme in this family was found in bovine pancrease, so it is also called pancreatic ribonuclease. However, other members in the family are found in other tissues, such as liver and kidney. Therefore, the term pancreatic ribonuclease is not proper as an ontology term for molecular activity.
    • Propagated endonuclease activity to the root.
    • The rest of MFs are all binding terms, so did not propagate.
  • CC
    • RNase A is secreted and is involved in defense response. See review http://ini.sagepub.com/content/19/1/86.long
    • Propagated extracellular space to the root.
    • Secretary granules and cytoplasm are not propagated because they are based on immunostaining.
  • BP
    • Propagate RNA phosphodiester bond hydrolysis, endonucleolytic and RNA catabolism to the root.
    • Positive regulation of cell proliferation is related to angiogenesis. Should it be propagated?
    • Propagate angiogensis to the angenin clade.
    • Propagate defense response to bacterium and antobacteral humoral response to the root.