17 March 2015 PAINT Conference Call

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PAINT conference call minutes, March 17rd, 2015

Participants:

Agenda

  • Timing for phasing out species specific GAFs (Karen)
    - At the last PAINT meeting, during discussion of Rama's question about use of the "Ref Genome" versus "GO Central" sources, Suzi talked about the plan to change the flow of GO annotations from PAINT to MODs so that they will all go to UniProt, and then get picked up by MODs from there, instead of from species specific GAFs, if I understood correctly.
    - The MGI GO group discussed this at our weekly meeting, and we would like to know what is the time frame for eliminating the species specific GAFs? We need a minimum of 30 days notice in order to get software changes in place to be able to accomodate this change. Has a plan been announced to the Consortium as a whole?
  • Log your curation
  • Family presentation (Huaiyu) - PTHR11437
    • It is an RNase A family (EC 3.1.27.5)
    • MF
      • The first enzyme in this family was found in bovine pancrease, so it is also called pancreatic ribonuclease. However, other members in the family are found in other tissues, such as liver and kidney. Therefore, the term pancreatic ribonuclease is not proper as an ontology term for molecular activity.
      • Propagated endonuclease activity to the root.
      • The rest of MFs are all binding terms, so did not propagate.
    • CC
      • RNase A is secreted and is involved in defense response. See review http://ini.sagepub.com/content/19/1/86.long
      • Propagated extracellular space to the root.
      • Secretary granules and cytoplasm are not propagated because they are based on immunostaining.
    • BP
      • Propagate RNA phosphodiester bond hydrolysis, endonucleolytic and RNA catabolism to the root.
      • Positive regulation of cell proliferation is related to angiogenesis. Should it be propagated?
      • Propagate angiogensis to the angenin clade.
      • Propagate defense response to bacterium and antobacteral humoral response to the root.