2010 GO-camp Response to terms issues

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  • how will these relate to signaling terms and to final cellular effect
  • What evidence code should be used to 'response to' annotations?
    • (A) For example in PMID: 2071672, the authors say "Exposure of the latter cells to 45 degrees C resulted in over 15-fold increase in the apparent level of the 25-kD IAP protein, confirming that its expression is regulated by heat shock". Should this protein (Q00649) be annotated to "response to heat" by IDA or IEP?
    • (B) Similar to (A) example: "Two highly divergent human MHC class I genes, MICA (Q29983) and MICB (Q29980), are regulated by promoter heat shock elements", protein: PMID: 8901601
    • (C) Q16576 Sc RBBP7 (aka RBAP46) is annotated to "cellular heat acclimation" by IDA from PMID:7503932. Is this annotation correct?
    • Transcription factors: O35780 (BHE40_RAT) is annotated to "entrainment of circadian clock" from PMID 12397359. The experiments show it is a transcription factor for genes involved in the circadian clock. Two questions: (i) is the term correct? or should it be annotated to the parent (regulation of circadian rhythm); (ii) is the IDA evidence code correct?
      • The F/P transcription regulator activity IDA annotations are missing. Is there any way we could have checks that would catch that?



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