2010 GO camp Geneva minutes
Day 1 morning session
9:00 Introductions and objectives of the meeting
- Introductions & Logistics: Serenella Ferro Rojas
- Poll for Thursday lunch reservations, depending on weather.
- Dinner at Brasserie la Bourse on the Carouge
- ~ 1.9 km from meeting site
Friday Reception at noon for Amos Bairoch celebration of the Otto Naegeli prize.
Introductions
Goals: Pascale Gaudet
GO – Ontology, annotation, tools and technical aspects
Chairs: Serenella Ferro Rojas and Pascale Gaudet
GO overview
An introduction to the GO ontology : terms, definitions, synonyms, relationships, cross-products. Jane Lomax
- Inter-ontology links
- Most tools don't make inferences across the ontoogies. Make redundant annotations.
- Cross products
- between GO ontologies
- external ontologies (cell ontology; CHEBI)
- Ontology development
- large scale targeted projects
- logical consistency
- small scale requests (Sourceforge tracker; future via Amigo)
Q/A: classical relationships (e.g. part_of within an ontology) are subset of cross-products.
Annotation Process
- General overview of the annotation guidelines used by GO, and contributing resources. Rama Balakrishnan
- Annotation guidelines
Goal:say as much as possible about a gene product. Be useful to bench and computational biologists.
- GO annotation: Gene product association with GO terms and other info.
- Core
- gene product identifiers
- GO term
- Reference
- Evidence code
- Additional info
- qualifiers
- with/from
- Annotation detail (16)
- Isoform
- Core
- Sources
- Manual
- Automated
- PAINT (new)
- inter-ontology inferences (new)
Differences between previous GO camps and this one. This one more internal and focused on strengthening guidelines.
- Challenges ...
- Avoiding redundancy.
- Authoritative sources
- General overview UniProtKB/SwissProt manual annotation. Serenella (15 min)
10: 30 Binding documentation
- Chairs: Ruth Lovering and Ursula Hinz
- Minutes: Jim Hu - Damien Lieberherr
- Working group: 2010_GO_camp_working_groups_composition
- Working group notes: Binding documentation issues
12:30 Lunch