Acts upstream of, positive effect

Overview

The acts upstream of gene product, positive effect to GO term relation when the mechanism relating a gene product's activity to a Biological Process is known and the activity occurs before the Biological Process but is neither an integral part of the process, nor an integral part of a process that regulates it and is required for the process to occur.

Examples of Usage

Genes involved in Ras lipidation act usptream of, postive effect in Ras protein signal transduction

• Ras signal transduction
• Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases.

Genes involved in glycine transport into the mitochondrion act upstream of, positive effect in heme biosynthesis

Characterization of Human and Yeast Mitochondrial Glycine Carriers with Implications for Heme Biosynthesis and Anemia.

Relations Ontology

acts upstream of, positive effect

Review Status

Last reviewed: March 9, 2018

Back to: Annotation Relations