Annotating ligand-receptor pathways: Difference between revisions
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[[Category: Annotation]] | [[Category: Annotation Guidelines]] | ||
Latest revision as of 09:09, 15 April 2019
TO BE REVIEWED
General ligand-receptor pathway
Stimulus
- regulation of signaling pathway
Ligand
- signaling pathway
- regulation of other cellular processes
Receptor
- signaling pathway
- regulation of other cellular processes
Signaling molecules
- signaling pathway
- regulation of other process(es)
- regulation of gene-specific transcription
- regulation of translation
- (regulation of) transcription in response to stimulus ligand
- (regulation of) transcription involved in other process(es)
- (regulation of ) other cellular process(es)
Transcription factors*
- signaling pathway
- regulation of transcription involved in other process(es)
Target
- cellular response to stimulus
- other process(es)
- regulation of other processes
- We would not consider annotating the core transcription machinery to the downstream (other) processes that the target is involved in unless the transcription factor is gene-specific, in which case we would annotate to regulation of transcription involved in other process(es)
Regulation of glucose transport
Insulin (ligand)
- insulin receptor signaling pathway
- regulation of glucose transport/homeostasis
Insulin receptor (receptor)
- Insulin receptor signaling pathway
- Regulation of glucose transport/homeostasis
IRS1, PI3K, PDK1, PKC (signaling molecules)
- Insulin receptor signaling pathway
- Regulation of glucose transport/homeostasis
- Protein localization at cell surface (NTR: involved in response to insulin)
GLUT4 (target)
- Cellular response to insulin
- Glucose transport/homeostasis