Annotation Call September 9, 2014
Upcoming GOC meeting
http://wiki.geneontology.org/index.php/2014_Barcelona_GOC_Meeting_Agenda We are collecting agenda items for the next meeting. Please send us any items that you would like discussed.
Please check the reports for your GAF file and make efforts to fix them.
"Binding" term (GO:0005488)
The term "binding" GO:0005488 has been put on the do_not_manually_annotate list, therefore all annotations to this term should be reviewed.
There are 27 annotations direct to this term and all of them have ChEBI IDs in the with field, therefore in most cases a more granular term should be used or created.
Some of the CHEBI IDs are not found and some seem unsuitable for GO (e.g. strychnine).
These are the unique ChEBI IDs used and in the right hand column are potential GO terms that could be used for some of them;
|CHEBI ID||name||Possible GO term|
|CHEBI:15367||all-trans-retinoic acid||GO:retinoic acid binding|
|CHEBI:33217||3,3',5,5'-tetrabromobisphenol A||GO:organic cyclic compound binding|
|CHEBI:49809||2,2',5,5'-tetrachloro-4,4'-bis(methylsulfonyl)biphenyl||GO:organic cyclic compound binding|
|CHEBI:8925||ryanodine||GO:organic cyclic compound binding?|
The distribution of annotations is;
Ub/Ub-like functions (David H)
1) We need annotator feedback on the fate of 'ubiquitin thiolesterase activity' (GO:0004221). This term can either be obsoleted or merged into 'ubiquitinyl hydrolase activity' (GO:0036459). There has been an observation that many of the annotations to (GO:0004221) could actually be transferred to 'ubiquitin-specific protease activity' (GO:0004843). Annotators will need to reexamine the annotations to GO:0004221 and reannotate to either GO:0036459 or GO:0004843. See SF items:#11094 and #10519
2) Moving along with the E1,E2, E3 terms, GO:0019787 small conjugating protein ligase activity suffers from the same issues as the original ubiquitin ligase terms. We need to revamp the MF ontology for the other small proteins in the same way that we did for the ubiquitin activating, ligase and conjugating enzymes. Looking at annotations to GO:0019787, it appears that all three types of enzyme activity have been annotated using this term. We need to go back and reexamine those annotations once this part of the ontology has been cleaned up. See SF item #11026