Annotation Conf. Call, July 28, 2015: Difference between revisions
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Typically mitophagy is dependent on PARK2 / parkin (Uniprot O60260). However, in PMID:25215947, authors show that AMBRA1 (Q9C0C7) (in presence of chemical inducers of mitochondrial depolarisation such as FCCP) initiates mitophagy independent of PARK2 / parkin. | Typically mitophagy is dependent on PARK2 / parkin (Uniprot O60260). However, in PMID:25215947, authors show that AMBRA1 (Q9C0C7) (in presence of chemical inducers of mitochondrial depolarisation such as FCCP) initiates mitophagy independent of PARK2 / parkin. | ||
What to do now that independent_of relation is obsoleted? Simplest to create new term instead? e.g. “parkin-independent mitophagy in response to mitochondrial depolarization”. <br /> | What to do now that independent_of relation is obsoleted? Simplest to create new term instead? e.g. “parkin-independent mitophagy in response to mitochondrial depolarization”. <br /> | ||
NB | NB Examples of parkin-independent mitophagy:<br /> | ||
PMID: 25349190 "Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain."<br /> | PMID: 25349190 "Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain."<br /> | ||
PMID: 24176932 "Loss of iron triggers PINK1/Parkin-independent mitophagy."<br /> | PMID: 24176932 "Loss of iron triggers PINK1/Parkin-independent mitophagy."<br /> | ||
Paul Denny, UCL Functional Annotation Group. | Paul Denny, UCL Functional Annotation Group. | ||
Revision as of 11:11, 21 July 2015
Agenda
Overview by ontology editors
Why certain relations were going to be obsoleted
Example papers
Obsoleted relationship:
independent_of
PMID:25215947
Typically mitophagy is dependent on PARK2 / parkin (Uniprot O60260). However, in PMID:25215947, authors show that AMBRA1 (Q9C0C7) (in presence of chemical inducers of mitochondrial depolarisation such as FCCP) initiates mitophagy independent of PARK2 / parkin.
What to do now that independent_of relation is obsoleted? Simplest to create new term instead? e.g. “parkin-independent mitophagy in response to mitochondrial depolarization”.
NB Examples of parkin-independent mitophagy:
PMID: 25349190 "Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain."
PMID: 24176932 "Loss of iron triggers PINK1/Parkin-independent mitophagy."
Paul Denny, UCL Functional Annotation Group.