Annotation Conf. Call, May 12, 2015: Difference between revisions

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(Created page with "Category:Annotation Working Group ==Agenda== ===Transferring col-16 data for ISS (Becky)=== We would like to discuss some rules to transfer col-16 data for ISS annotatio...")
 
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===Transferring col-16 data for ISS (Becky)===
===Transferring col-16 data for ISS (Becky)===
We would like to discuss some rules to transfer col-16 data for ISS annotations.
We would like to discuss some rules to transfer col-16 data for ISS annotations.
* If the annotation being transferred has an annotation extension (which may, of course, subsequently need to be modified if it contains any species-specific components), then the transfer will be allowed, even if an IDA- or IPI-evidenced annotation to the same, or descendant, GO term already exists.
* If the annotation being transferred has an annotation extension (which may, of course, subsequently need to be modified if it contains any species-specific components), then the transfer will be allowed, even if an IDA- or IPI-evidenced annotation to the same, or descendant, GO term already exists. These annotations should only be transferred on a case-by-case basis where the curator considers there is good evidence that the C16 information would be conserved between the two entries.
These annotations should only be transferred on a case-by-case basis where the curator considers there is good evidence that the C16 information would be conserved between the two entries.
* If the annotation being transferred does *not* have an extension, then the transfer will be disallowed, as per the current rules.
* If the annotation being transferred does *not* have an extension, then the transfer will be disallowed, as per the current rules.
===Ion channels- Ontology overhaul (David)===
===Complexes in CC ===
New guidelines for creating complexes in GO
old def: "Any macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators]
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new def: "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators]
<br>
new definition comment: "A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose affinity complex; 3) proteins with the same function but with either no demonstrable physical link or one that can be inferred by sequence homology; 4) any complex where the only evidence is based on genetic interaction data."

Revision as of 12:01, 8 May 2015


Agenda

Transferring col-16 data for ISS (Becky)

We would like to discuss some rules to transfer col-16 data for ISS annotations.

  • If the annotation being transferred has an annotation extension (which may, of course, subsequently need to be modified if it contains any species-specific components), then the transfer will be allowed, even if an IDA- or IPI-evidenced annotation to the same, or descendant, GO term already exists. These annotations should only be transferred on a case-by-case basis where the curator considers there is good evidence that the C16 information would be conserved between the two entries.
  • If the annotation being transferred does *not* have an extension, then the transfer will be disallowed, as per the current rules.

Ion channels- Ontology overhaul (David)

Complexes in CC

New guidelines for creating complexes in GO old def: "Any macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators]
new def: "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators]
new definition comment: "A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose affinity complex; 3) proteins with the same function but with either no demonstrable physical link or one that can be inferred by sequence homology; 4) any complex where the only evidence is based on genetic interaction data."