Annotation Conf. Call 2016-02-23

Bluejeans

• Recurring meeting URL: https://bluejeans.com/993661940

Agenda

• GOC Meeting - Geneva, April 2016
  • http://wiki.geneontology.org/index.php/2016_Geneva_GOC_Meeting_Logistics
  • http://wiki.geneontology.org/index.php/2016_Geneva_GOC_Meeting_Agenda
• Review new IGI documentation
  • Based on comments from the last call, there's a draft of the revised documentation here:
    • http://wiki.geneontology.org/index.php/IGI_Documentation
    • Specific changes were made wrt: 1) the section on experiments where expression of one gene alters the phenotype of a mutation in a second gene, 2) additional IGI examples, 3) additional example of when NOT to use IGI - rescue of mutant phenotype by expression of the same gene
• Call for information
  • We would like to develop documentation on GO annotation from experiments using cell lines
  • What types of cell lines are acceptable? What cell lines can reasonably be used as models for in vivo cell types? Should we document cell lines that are traditionally used to model in vivo cells, C2C12---myoblast? When do the experiments reflect normal biology vs pathology, e.g. cancer biology?
  • If your group has documentation or policies on this, please forward to DavidH and Kimberly
• New miRNA guidelines
  • Reminder to please look at updates to miRNA annotation guidelines sent by Rachael on 12th February 2016 in an email entitled "Updates to miRNA annotation guidelines". If no comments are received by Friday 26th February we will assume everyone is happy with these changes and they will be added to the existing guidelines.
• Annotation Consistency Exercise
  • The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. PMID:25267624
  • DavidH will lead the discussion and we'll talk about conventional annotations and LEGO representation
  • Of particular interest is how/when to link metabolic activities to behavioral processes that are revealed by phenotypic analysis.