Difference between revisions of "Annotation Conf. Call 2016-09-27"

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*[https://docs.google.com/spreadsheets/d/1nAquF0oXHU6d638Q97ZeQ7K7DOhuru84-rOMEL4A114 Google spreadsheet] sent out by ontology editors
 
*[https://docs.google.com/spreadsheets/d/1nAquF0oXHU6d638Q97ZeQ7K7DOhuru84-rOMEL4A114 Google spreadsheet] sent out by ontology editors
 
*List of GO group members on github under [https://github.com/orgs/geneontology/people people directory]
 
*List of GO group members on github under [https://github.com/orgs/geneontology/people people directory]
 +
**Does everyone have a github account?
 +
**What is required for someone to be listed under People for the GO project?
 +
**What is required to see everyone listed under People for the GO project?
  
 
[[Category: Annotation Working Group]]
 
[[Category: Annotation Working Group]]

Revision as of 11:47, 26 September 2016

Bluejeans URL: https://bluejeans.com/993661940

Agenda

Annotation Consistency Exercise

Abstract Chemotaxis, or directional movement toward extracellular chemical gradients, is an important property of cells that is mediated through G-protein-coupled receptors (GPCRs). Although many chemotaxis pathways downstream of Gβγ have been identified, few Gα effectors are known. Gα effectors are of particular importance because they allow the cell to distinguish signals downstream of distinct chemoattractant GPCRs. Here we identify GflB, a Gα2 binding partner that directly couples the Dictyostelium cyclic AMP GPCR to Rap1. GflB localizes to the leading edge and functions as a Gα-stimulated, Rap1-specific guanine nucleotide exchange factor required to balance Ras and Rap signaling. The kinetics of GflB translocation are fine-tuned by GSK-3 phosphorylation. Cells lacking GflB display impaired Rap1/Ras signaling and actin and myosin dynamics, resulting in defective chemotaxis. Our observations demonstrate that GflB is an essential upstream regulator of chemoattractant-mediated cell polarity and cytoskeletal reorganization functioning to directly link Gα activation to monomeric G-protein signaling.

Meetings

Next GOC Meeting - USC, Los Angeles, CA, November 4-6, 2016

  • Please indicate on the Meeting Logistics Page if you plan to come.
  • We are now planning a one-day Noctua/LEGO training session for the Monday (November 7th) following the general consortium meeting. Please indicate on the logistics page if you are definitely staying for that so Paul T. can arrange for a meeting room.

GO Group Contacts

  • Google spreadsheet sent out by ontology editors
  • List of GO group members on github under people directory
    • Does everyone have a github account?
    • What is required for someone to be listed under People for the GO project?
    • What is required to see everyone listed under People for the GO project?