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Line 51: |
Line 51: |
| | comment | | | comment |
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| | | | |''Molecular Function'' |
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| |2a
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| |-
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| |gflB
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| |GO:0001965 G-protein alpha-subunit binding
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| |IPI
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| |gpaB (DDB_G0276267)
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| |1b
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| |-
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| |gflB
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| |GO:0005515 protein binding
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| |IPI
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| |rapA (DDB_G0291237)
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| |happens_during GO:0001965 G-protein alpha-subunit binding
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| |s2e + 2b
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| |-
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| |gflB
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| |NTR: activation of Rap1 GTPase activity
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| |IMP
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| |part_of GO:0071320 cellular response to cAMP
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| |-
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| |gflB
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| |GO:0001965 G-protein alpha-subunit binding
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| |IPI
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| |gpaB
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| |occurs_at SO:0100014 n_terminal_region
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| |SO term is defining where gflB binds to gpaB - need new relation?
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| |-
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| |gflB
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| |GO:0031267 small GTPase binding
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| |IPI
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| |RapA
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| |happens_during, has_direct_input activation of GTPase activity, gpaB
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| |maybe Rap GTPase binding should be added as child, all others are there
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| |-
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| |gflB
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| |GO:0017034 Rap guanyl-nucleotide exchange factor activity
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| |IDA
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| |has_input, happens_during, occurs_at rapA,activation of GTPase activity, cell cortex
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| |-
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| |gflB
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| |GO:0005543 phospholipid binding
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| |IDA
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| |occurs_at SO:0100014 n_terminal_region
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| |Fig.5SA
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| |-
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| |gflB
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| |GO:0001965 G-protein alpha-subunit binding
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| |IPI
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| |gpaB
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| |activated by GppNHp (CHEBI:78408)
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| |or should this be GTP (CHEBI:15996); pg 460 left column
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| |-
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| |gflB
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| |GO:0017034 Rap guanyl-nucleotide exchange factor activity
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| |IDA
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| |has regulation target: rapA UniProt: P18613
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| |pg 461 left column
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| |-
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| |GflB
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| |GO:0005515 protein binding
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| |IPI
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| |GpaB
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| |-
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| |GflB
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| |GO:0005085 guanyl-nucleotide exchange factor activity
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| |IMP
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| |-
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| |GflB
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| |GO:0005085 guanyl-nucleotide exchange factor activity
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| |IDA
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| |has_input Rap1
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| |-
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| |GflB
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| |GO:0005515 protein binding
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| |IPI
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| |Rap1
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| |has_participant GpaB
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| |depends on Ga2 being bound to GPPnHp
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| |-
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| |GflB
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| |GO:0005515 protein binding
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| |IPI
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| |GpaB
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| |-
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| |GflB
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| |GO:0005515 protein binding
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| |IPI
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| |RACB, RACL
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| |-
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| |GflB
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| |GO:0005085 guanyl-nucleotide exchange factor activity
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| |IDA
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| |has_direct_input UniProtKB:P18613
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| |RAP1 is target
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| |-
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| |gpaB
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| |GO:0005515 protein binding
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| |IPI
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| |gflB (DDB_G0286773)
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| |1b
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| |-
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| |gpaB
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| |NTR: Ras guanyl-nucleotide exchange factor binding
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| |IC
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| |GO:0005515 protein binding
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| |1
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| |-
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| |gpaB
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| |GO:0032092 positive regulation of protein binding
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| |IDA
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| |has_regulation_target AND has_regulation_target gflB (DDB_G0286773) AND rapA (DDB_G0291237
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| |2b
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| |-
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| |gpaB
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| |GO:0005515 protein binding
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| |IPI
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| |GflB
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| |Possibly a new term for guanylyl-nucleotide exchange factor binding? Also, see above.
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| |-
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| |gpaB
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| |GO:0005515 protein binding
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| |IPI
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| |gflB
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| |part_of GO:0007186 G-protein coupled receptor signaling pathway
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| |maybe new term 'nucleitide exchange factor binding? Cannot easily annotate that only activated (GTP bound) gpbA binds to gflB
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| |-
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| |GpaB
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| |GO:0005515 protein binding
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| |IPI
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| |GflB
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| |-
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| |GskA
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| |GO:0004674 protein serine/threonine kinase activity
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| |IDA
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| |has_direct_input GflB
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| |-
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| |GskA
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| |GO:0004674 protein serine/threonine kinase activity
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| |IMP
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| |happens_during, part_of, has_regulation_target GO:0071320, GO:1905097, GflB
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| |full extension: happens_during GO:0071320, part_of GO:1905097, has_regulation_target GflB (GO:0071320 = cellular response to cAMP; GO:1905097 = regulation of guanyl-nucleotide exchange factor activity)
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| |-
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| |gskA
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| |GO:0004674 protein serine/threonine kinase activity
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| |IDA
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| |has_input gflB (DDB_G0286773)
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| |5d
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| |-
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| |GskA
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| |GO:0004674 protein serine/threonine kinase activity
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| |ISS
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| |human GSK3b
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| |has input GflB
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| |-
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| |GskA
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| |GO:0004674 protein serine/threonine kinase activity
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| |IDA
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| |has_direct_input UniProtKB:Q54L90
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| |-
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| |RACB
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| |GO:0005515 protein binding
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| |IPI
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| |GflB
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| |Fig. S1
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| |-
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| |RACL
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| |GO:0005515 protein binding
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| |IPI
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| |GflB
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| |Fig. S1
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| |-
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| |rapA
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| |GO:0005515 protein binding
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| |IPI
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| |gflB (DDB_G0286773)
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| |happens_during GO:0001965 G-protein alpha-subunit binding
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| |s2e + 2b
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| |-
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| |rapA
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| |GO:0005515 protein binding
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| |IPI
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| |GflB
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| |-
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| |rapA
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| |GO:0005515 protein binding
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| |IPI
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| |GflB
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| |happens_during activation of GTPase activity
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| |new term 'nucleitide exchange factor binding?
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| | ''Cellular Component''
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| |- | | |- |
| |- | | | gene |
| | gflB
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| | GO:0005737 cytoplasm
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| | IDA
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| | unstimulated cells
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| |-
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| | gflB
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| | GO:1904269 cell leading edge cell cortex
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| | IDA
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| | unstimulated cells
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| |-
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| | gflB
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| | GO:0005938 cell cortex
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| | IDA
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| | exists_during GO:0071320
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| | GO:0071320 = cellular response to cAMP; not sure how to capture cytoskeleton dependency, in conventional annotation extensions or LEGO; does the experiment with GflBP1 and LatA show plasma membrane GO:0005886?
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| |-
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| | gflB
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| | GO:0005737 cytoplasm
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| | IDA
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| | 5a
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| |-
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| | gflB
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| | GO:0005737 cytoplasm
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| | IDA
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| | exists_during asexual reproduction
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| |-
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| | gflB
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| | GO:0005938 cell cortex
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| | IDA
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| | exists_during response to cAMP
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| |-
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| | gflB
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| | GO:0031252 cell leading edge
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| | IDA
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| | exists_during chemotaxis to cAMP
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| |-
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| | gflB
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| | GO:0005886 plasma membrane
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| | IDA
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| | exists_during chemotaxis to cAMP
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| | annotated 'plasma membrane' because of latA + domain expression experiments, also Supp Fig. 5A shows Phospholipid binding (see MF)
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| |-
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| | GflB
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| | GO:0005938 cell cortex
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| | IDA
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| |-
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| | GflB
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| | GO:0031252 cell leading edge
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| | IDA
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| | exists_during chemotaxis (GO:0006935)
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| |-
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| | gflB
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| | GO:0005737 cytoplasm
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| | IDA
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| | pg 462 right column
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| |-
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| | gflB
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| | GO:0031252 cell leading edge
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| | IDA
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| | exists during: cell chemotaxis GO:0060326
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| | gradient treatment to induce chemotaxis; pg 462 right column
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| |-
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| | gflB
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| | GO:0005938 cell cortex
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| | IDA
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| | happens during: cellular response to cAMP GO:0071320
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| | uniform or global treatment with cAMP; pg 462 right column
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| |-
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| | gflB
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| | GO:0031256 leading edge membrane
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| | IDA
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| |-
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| | gflB
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| | GO:0031252 cell leading edge
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| | IDA
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| |-
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| | gflB
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| | GO:1904269 cell leading edge cell cortex
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| | IDA
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| | localization_dependent_on ?Galpha2
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| | requires binding of active Galpha
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| |-
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| | Raf1
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| | GO:1904269 cell leading edge cell cortex
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| | IDA
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| |-
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| | Ral
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| | GO:1904269 cell leading edge cell cortex
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| | IDA
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| |-
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| | Rap1
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| | GO:0009279 cell outer membrane
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| | IDA
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| |-
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| | Rap1
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| | GO:0005886 plasma membrane
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| | IDA
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| |-
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| | rapA
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| | GO:0005886 plasma membrane
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| | IDA
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| | 3a
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| |-
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| | rapA
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| | GO:0005886 plasma membrane
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| | IDA
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| |-
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| | rasG
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| | GO:0005886 plasma membrane
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| | IDA
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| | 3a
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| |-
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| | RasG
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| | GO:0005886 plasma membrane
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| | IDA
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| |-
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| | RasG
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| | GO:0009279 cell outer membrane
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| | IDA
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| |-
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| | RasG
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| | GO:0005886 plasma membrane
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| | IDA
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| | | GOID term |
| | | evidence code |
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| | | comment |
| |} | | |} |
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