Annotation Conf. Call 2017-01-24: Difference between revisions
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[https://www.ncbi.nlm.nih.gov/pubmed/11595184 Paper: C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.] | [https://www.ncbi.nlm.nih.gov/pubmed/11595184 Paper: C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.] | ||
*Questions: | |||
**How best to capture the role of O2 wrt the hydroxylase activity of EGL-9? | |||
***O2 is described as a co-substrate along with HIF-1, and is absolutely required for the hydroxylation. | |||
= Minutes = | = Minutes = | ||
[[Category: Annotation Working Group]] | [[Category: Annotation Working Group]] |
Revision as of 09:48, 24 January 2017
Bluejeans URL
https://bluejeans.com/993661940
Agenda
GO Meeting Reminder
- Corvallis, Oregon - June 1-3rd, Noctua Workshop - June 4th, Reactome Workshop - June 5th
- Meeting Registration Site
- Meeting Agenda
github Tickets
- New qualifiers for biological process
- Will be discussed on the February 14th annotation call, but please look at the ticket and comment there, if needed.
LEGO Models
MGI - David and Karen
WB - Kimberly
Model: Regulation of HIF-1 under normoxic conditions
- Questions:
- How best to capture the role of O2 wrt the hydroxylase activity of EGL-9?
- O2 is described as a co-substrate along with HIF-1, and is absolutely required for the hydroxylation.
- How best to capture the role of O2 wrt the hydroxylase activity of EGL-9?