Annotation Conf. Call 2017-01-24

Bluejeans URL

https://bluejeans.com/993661940

Agenda

GO Meeting Reminder

• Corvallis, Oregon - June 1-3rd, Noctua Workshop - June 4th, Reactome Workshop - June 5th
• Meeting Registration Site
• Meeting Agenda

github Tickets

• New qualifiers for biological process
  • Will be discussed on the February 14th annotation call, but please look at the ticket and comment there, if needed.

LEGO Models

MGI - David and Karen

Model: PMID-12771146-KRC

Paper: The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1.

WB - Kimberly

Model: Regulation of HIF-1 under normoxic conditions

Paper: C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

• Questions:
  • How best to capture the role of O2 wrt the hydroxylase activity of EGL-9?
    • O2 is described as a co-substrate along with HIF-1, and is absolutely required for the hydroxylation.
    • Not capturing 2-oxoglutarate and Fe2+ in this model.