Annotation Conf. Call 2017-01-24

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Bluejeans URL

https://bluejeans.com/993661940

Agenda

GO Meeting Reminder

github Tickets

LEGO Models

MGI - David and Karen

Model: PMID-12771146-KRC

Paper: The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1.

WB - Kimberly

Model: Regulation of HIF-1 under normoxic conditions

Paper: C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

  • Questions:
    • How to annotate the role of substrates and co-factors wrt the hydroxylase activity of EGL-9?
      • Capturing the protein substrate, HIF-1.
      • Other players: O2, Fe2+, 2-oxo-glutarate

Minutes