Bluejeans URL
Agenda
Meeting Reminder
- Next Consortium Meeting: June 1-3, 2017 in Corvallis, Oregon
- Noctua Workshop on June 4th
- Reactome Workshop on June 5th
Qualifiers and Relations in GO
- Qualifiers are used in GAF and GPAD
- Relations are used in GPAD, Annotation Extensions, and LEGO models
- In GPAD, the explicit relations between a gene/gene product and GO terms are ontology-specific:
- involved_in a BP
- enables a MF
- part_of a CC
- Annotation extension relations 'extend' the meaning of the GO term, providing additional biological context
- In LEGO models, relations describe the context in which activities (GO MFs) occur and how activities relate to one another
New Relations for Modifying a Gene's Role in a Biological Process
Link to github Discussion
- This issue is about adding more relations to the list that curators currently use to describe the relationship between a gene/gene product and a BP GO term.
- We have talked about doing something like this for a long time, with the overall goal being a more accurate representation of biology.
- The current proposal is to add:
- acts_upstream_of_or_within
- acts_upstream_of
- involved_in_regulation_of
- involved_in_or_involved_in_regulation_of
- involved_in
- involved_in_regulation_of
- involved_in_negative_regulation_of
- involved_in_positive_regulation_of
- For discussion:
- Use of 'within' vs 'involved_in'
- Definitions
- Formal definitions exist, but curators would like guidance on how experimental results inform selection of a given relation
- LEGO GPAD outputs
- How will LEGO annotations translate back to GPAD annotations, specifically wrt regulates relations?
- Where can curators view all of the relations used in GO, their definitions, and usage statements and examples?
- GO website
- Annotation Documentation
- Ontology browser
- GO wiki
- github
- Google docs
- OLS
Jenkins Jobs
February 28th Call
- Discussion of LEGO Models
- Sabrina (ZFIN)
- Midori (PomBase)
Minutes