Annotation Conf. Call 2018-01-09
Meeting URL
Agenda
Review of Cambridge meeting action items and milestones for 2018-05 GOC meeting in NYC
In geneontology/go-annotation on github, there is a Milestone '2018-05 GOC meeting'
Annotation Review
HTP Annotations
- Review HTP annotations
- Forward genetic screens - needs clarification
- HTP-types will not be allowed as evidence for ISS+ISO
Signaling Workshop
In geneontology/go-annotation on github, there is a label 'GO workshop signaling 2017'
General Signaling Issues
- Review annotation to 'receptor ligand activity' (GO:0048018)
- MP cell surface receptor signaling pathway
Ca2+ Signaling - Fertilization
GPCR-mediated cAMP Signaling
- Review annotations to 'cAMP biosynthetic process'
- Review annotation for GPCR
- NTR: regulation terms for adenylate cyclase-activating adrenergic receptor signaling pathway
- cAMP biosynthetic process - merges & obsoletion
- GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway... missing parent
JAK/STAT Signaling Pathway
MAPK Cascade
Canonical Wnt Signaling Pathway
- PAINT:PTN000226268 Wnt signaling pathway to positive regulation of...
- Review annotations to beta catenin
- PANTHER:PTN000139394: remove wnt binding annotation to smoothened receptors
- https://github.com/geneontology/go-ontology/issues/14275 NTR: “receptor ligand agonist activity” and “receptor ligand antagonist activity”]
Requests for Proposals
Protein Complexes Working Group
- Inferring MF annotations for complex members
- Proposal for guidelines for using contributes_to
- should we really use "colocalizes_with" with cc complex terms
- Protein complex representation in Noctua
- Do we have to hard-code CC complex terms to MF and BP relationships in the ontology?
- Working group established, one meeting in late November
- Next meeting?
Annotation Relations - Cellular Component
- should we really use "colocalizes_with" with cc complex terms
- Relations to describe gene product - component annotation
InterPro2GO Pipeline
- InterPro2GO pipeline
- Need to establish a working group here
Engaging External Experts
- Recommendations and guidelines for next time we engage an external group of experts
- Need to have a working group or responsible persons here, too
Requests for Guidelines
GO-CAM and Noctua
- QC for Noctua models
- New qualifiers for biological processes - including how to deal with legacy annotations
Minutes
- On call: