Annotation Conf. Call 2018-01-09
Meeting URL
Agenda
Review of Cambridge meeting action items and milestones for 2018-05 GOC meeting in NYC
In geneontology/go-annotation on github, there is a Milestone '2018-05 GOC meeting'
Requests for Proposals
Protein Complexes Working Group
- Inferring MF annotations for complex members
- Proposal for guidelines for using contributes_to
- should we really use "colocalizes_with" with cc complex terms
- Protein complex representation in Noctua
- Do we have to hard-code CC complex terms to MF and BP relationships in the ontology?
- Working group established, one meeting in late November
- Next meeting?
- Updates from Birgit:
- Latest: I have to design a user survey to answer some of the open questions from our call. It's on my to-do list for this month.
- Other discussion points rely on us finishing the complex IDs. Our developers were rather stretched this autumn so it's taking a little longer than expected but they are back on it and it's really close!
Annotation Relations - Cellular Component
- should we really use "colocalizes_with" with cc complex terms
- Relations to describe gene product - component annotation
- Draft proposal (Kimberly) - need input from Chris on RO
- Relations between gene products and organelles/locations
- Relations between gene products and macromolecular complexes
Annotation Relations - Biological Process
Cellular Component Annotations for Transmembrane Proteins
https://github.com/geneontology/go-annotation/issues/1621
InterPro2GO Pipeline
- InterPro2GO pipeline
- Need to establish a working group here
Engaging External Experts
- Recommendations and guidelines for next time we engage an external group of experts
- Need to have a working group or responsible persons here, too
Annotation Review
HTP Annotations
- Review HTP annotations
- HTP_Guidelines_condensed_version
- Forward genetic screens - may need further clarification and examples of what is/is not high throughput
- HTP_Guidelines_condensed_version
- HTP-types will not be allowed as evidence for ISS+ISO
- Set date for meeting to discuss ISS/ISO transfer from HTP to be discussed in Feb.
Signaling Workshop
In geneontology/go-annotation on github, there is a label 'GO workshop signaling 2017'
General Signaling Issues
- Review annotation to 'receptor ligand activity' (GO:0048018)
- MP cell surface receptor signaling pathway
Ca2+ Signaling - Fertilization
GPCR-mediated cAMP Signaling
- Review annotations to 'cAMP biosynthetic process'
- Review annotation for GPCR
- NTR: regulation terms for adenylate cyclase-activating adrenergic receptor signaling pathway
- cAMP biosynthetic process - merges & obsoletion
- GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway... missing parent
JAK/STAT Signaling Pathway
MAPK Cascade
Canonical Wnt Signaling Pathway
- PAINT:PTN000226268 Wnt signaling pathway to positive regulation of...
- Review annotations to beta catenin
- PANTHER:PTN000139394: remove wnt binding annotation to smoothened receptors
- https://github.com/geneontology/go-ontology/issues/14275 NTR: “receptor ligand agonist activity” and “receptor ligand antagonist activity”]
GO-CAM and Noctua
- No call tomorrow
- Software team has been working on the priority issues for Noctua 1.0 release
- QC for Noctua models
Protein2GO Reports
- Protein2GO users please remember to check the monthly reports and work on updating/fixing flagged annotations
Two Working Meetings
- January 22nd - 26th: Docathon at Berkeley
- February 12 - 16th: Ontology GitHub jamboree in Denver
Minutes
- On call: David H, George, Harold, Helen, Karen, Kimberly, Li, Liz, Pascale, Petra, Rachael, Rob, Sabrina, Sage, Sandra, Stacia, Stan, Suzi, Val