Difference between revisions of "Annotation Conf. Call 2018-05-22"

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(Cyclic nucleotide metabolic process and child terms (from GPCR signaling work))
(Annotation Review)
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== Annotation Review ==
 
== Annotation Review ==
 +
*'''AI:''' Add links to ontology tickets, and more rationale, to annotation review tickets.
 
*We should include ISS annotations in our annotation review pipeline.
 
*We should include ISS annotations in our annotation review pipeline.
 
*Protein2GO checks that the gene product referenced in the With/From for an ISS annotation still has a valid annotation.
 
*Protein2GO checks that the gene product referenced in the With/From for an ISS annotation still has a valid annotation.
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**Have the cyclic nucleotide metabolic process terms been used in the With/From for IC annotations?
 
**Have the cyclic nucleotide metabolic process terms been used in the With/From for IC annotations?
 
**Papers may show the effects on level of cyclic nucleotides, but no effect on a specific signaling pathway.
 
**Papers may show the effects on level of cyclic nucleotides, but no effect on a specific signaling pathway.
*'''AI:''' Add links to ontology tickets, and more rationale, to annotation review tickets.
+
 
  
  

Revision as of 07:21, 22 May 2018

Meeting URL

Agenda

Annotation Review

Cyclic nucleotide metabolic process and child terms (from GPCR signaling work)

New Today

Existing

Growth

Canonical Wnt Signaling

MAPK Cascade

Extracellular Matrix

GOC Meeting - NYC

Minutes

Presentations/Slides

  • Presentations and slides are available in the GO's Google drive
    • If you presented and your slides are not here, please add them.

SAB

  • SAB followed the GOC meeting
  • Report to come soon

Annotation Survey Results

GO-CAM/Noctua

  • Next call tomorrow, Wednesday, May 23rd at 11:00am EDT (see Google calendar)

Minutes

  • On call: Barbara, Giulia, Harold, Karen, Kimberly, Li, Liz, Pascale, Petra, Sabrina, Shur-Jen, Suzi L, Tanya

Annotation Review

  • AI: Add links to ontology tickets, and more rationale, to annotation review tickets.
  • We should include ISS annotations in our annotation review pipeline.
  • Protein2GO checks that the gene product referenced in the With/From for an ISS annotation still has a valid annotation.
  • We still have older ISS annotations with nothing in the With/From column; these should be reviewed and removed, or updated, as appropriate.

Cyclic nucleotide metabolic process and child terms (from GPCR signaling work)

  • Proposal is to obsolete these BP terms.
  • One issue:
    • Papers that describe a mutant phenotype that results in less cAMP; there is no in vitro assay for the enzymatic activity.
    • Is this sufficient evidence to make an IMP annotation to the MF, adenylate cyclase activity, if the gene product has similarity to known adenylate cyclases?
    • Have the cyclic nucleotide metabolic process terms been used in the With/From for IC annotations?
    • Papers may show the effects on level of cyclic nucleotides, but no effect on a specific signaling pathway.