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Meeting URL
Agenda
Annotation Review
Cyclic nucleotide metabolic process and child terms (from GPCR signaling work)
New Today
Existing
Growth
Canonical Wnt Signaling
MAPK Cascade
GOC Meeting - NYC
Minutes
- Agenda and Minutes
- GO managers will review action items and prioritize for the coming months
Presentations/Slides
- Presentations and slides are available in the GO's Google drive
- If you presented and your slides are not here, please add them.
SAB
- SAB followed the GOC meeting
- Report to come soon
Annotation Survey Results
GO-CAM/Noctua
- Next call tomorrow, Wednesday, May 23rd at 11:00am EDT (see Google calendar)
Minutes
- On call: Barbara, Giulia, Harold, Karen, Kimberly, Li, Liz, Michele, Pascale, Petra, Ruth, Sabrina, Shur-Jen, Stan, Suzi L, Tanya, Val
Annotation Review
- AI: Add links to ontology tickets, and more rationale, to annotation review tickets.
- We should include ISS annotations in our annotation review pipeline.
- Protein2GO checks that the gene product referenced in the With/From for an ISS annotation still has a valid annotation.
- We still have older ISS annotations with nothing in the With/From column; these should be reviewed and removed, or updated, as appropriate.
Cyclic nucleotide metabolic process and child terms (from GPCR signaling work)
- Proposal is to obsolete these BP terms.
- One issue:
- Papers that describe a mutant phenotype that results in less cAMP; there is no in vitro assay for the enzymatic activity.
- Is this sufficient evidence to make an IMP annotation to the MF, adenylate cyclase activity, if the gene product has similarity to known adenylate cyclases?
- Have the cyclic nucleotide metabolic process terms been used in the With/From for IC annotations?
- Papers may show the effects on level of cyclic nucleotides, but no effect on a specific signaling pathway.
- GO-CAM models will allow for multiple pieces of evidence; combinatorial code for conventional annotations?
Growth
- Made 'do not annotate'
- PAINT annotations will get flagged if they need to be reviewed
Canonical Wnt Signaling
- Please review and respond in the ticket if you have questions.
MAPK Cascade
- David and Sabrina will double-check if there is any additional work to do here.
- Please review and respond in the ticket if you have questions.