Annotation Conf. Call 2019-07-09

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Agenda

github submission for InterPro2GO mappings

Protein oligomerization terms in GO

  • Follow up to 2019-06-11 annotation conference call to review recommendations and actions
  • Proposal and Recommendations
  • Biological Process Annotations
  • Molecular Function Annotations
    • Protein Dimerization Activity (includes regulation of activity)
    • Annotations to some terms, e.g. protein homodimerization activity, should be handled by merge (in this case into 'identical protein binding')
    • For IC, NAS, and TAS evidence codes, recommend upgrading to an experimentally supported annotation (as per guidelines, e.g. identical protein binding with IPI) or removing
    • For IDA annotations, we'd like to convert as many of those as possible into IPI, even if the With field will contain the same ID as the annotated entity. This allows for consistent representation of binding annotations in GO.
      • ~350 IDA annotations to 'protein heterodimerization activity'. Are these all cases where the interactor could not be assigned an ID?
  • Gitter question from Petra

QC Reports

Pipeline Reports

Matrix QC checks

  • How is this work going for people?
  • Questions, comments?

GO-CAMs and Annotation Extensions

  • After USC hackathon in June, we formed a small working group to fully articulate the GO-CAM model specifications
  • This will allow uniform QC across workbenches, projects (e.g. Reactome and MOD imports)
  • Will also allow us to move forward with harmonizing AE relations used in GO-CAM and conventional annotation

Minutes

  • Present: