Annotation Conf. Call 2019-11-19: Difference between revisions
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(Created page with "= Agenda = == Progress Reports == *Reminder: due mid-December == Annotation Extension Relations == === 'activated by' and 'inhibited by' === *If the chemical or molecular enti...") |
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== Progress Reports == | == Progress Reports == | ||
*Reminder: due mid-December | *Reminder: due mid-December | ||
*Annotation Group [https://docs.google.com/document/d/15HObk9-uPxYrgHaOK6RKKCbGJybnOrdoIr4JtkUTdjM Template] | |||
*GO will generate annotation stats | |||
== Annotation Extension Relations == | == Annotation Extension Relations == | ||
=== 'activated by' and 'inhibited by' === | === 'activated by' and 'inhibited by' === |
Revision as of 18:42, 18 November 2019
Agenda
Progress Reports
- Reminder: due mid-December
- Annotation Group Template
- GO will generate annotation stats
Annotation Extension Relations
'activated by' and 'inhibited by'
- If the chemical or molecular entity performing the activation or inhibition acts directly on the gene product by binding to it and is believed to be an endogenous regulator:
- remove the 'activated by' or 'inhibited by' annotation extension
- create a new 'binding' annotation with an annotation extension of: 'directly positively regulates' or 'directly negatively regulates' the regulated activity of the gene product
- If the annotation is to a binding term, and the extension is 'activated by' the chemical or molecular entity bound:
- remove the 'activated by' annotation extension and replace with 'has input'
- the annotations will be used in the future to create or check the logical definitions in the ontology
- If the inhibitor acts by competitively binding to an entity required for the activity of another gene product:
- proposal: the activity of the inhibitor 'directly negatively regulates' the activity of the other gene product
- Examples:
- Two DNA-binding transcription factors that compete for overlapping regulatory sequences
- A gene product that binds and sequesters an enzyme substrate
- A decoy receptor that binds and sequesters a ligand
- secreted frizzled-related proteins
Noctua Form 2.0 Demo
Minutes
- Present: