Annotation Conf. Call 2020-01-28: Difference between revisions
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**https://github.com/geneontology/go-annotation/issues/2718 | **https://github.com/geneontology/go-annotation/issues/2718 | ||
**'activated by' had been used to identify a chemical substance that increases the activity of the gene product. | **'activated by' had been used to identify a chemical substance that increases the activity of the gene product. | ||
**We would like to instead model this | **We would like to instead model this as: | ||
**The | ***GeneProduct 1 'enables' binding (GO:0005488) 'has_input' (some chemical), 'directly_positively_regulates' molecular function | ||
***GeneProduct 1 'enables' molecular function | |||
**The aims are to: 1) model regulatory events in terms of activities enabled by gene products, and 2) capture regulatory molecules, but not necessarily things like co-factors. | |||
**Sample GO-CAM model: http://noctua.geneontology.org/editor/graph/gomodel:5db9c9a500000296 | **Sample GO-CAM model: http://noctua.geneontology.org/editor/graph/gomodel:5db9c9a500000296 | ||
Revision as of 17:42, 27 January 2020
Agenda and Minutes
- Present:
Annotation Relations
- Goal is to review use of relations across annotations (standard and GO-CAM) and the ontology to ensure consistency wherever possible
- Relations to discuss this week:
- 'activated by'
- https://github.com/geneontology/go-annotation/issues/2718
- 'activated by' had been used to identify a chemical substance that increases the activity of the gene product.
- We would like to instead model this as:
- GeneProduct 1 'enables' binding (GO:0005488) 'has_input' (some chemical), 'directly_positively_regulates' molecular function
- GeneProduct 1 'enables' molecular function
- The aims are to: 1) model regulatory events in terms of activities enabled by gene products, and 2) capture regulatory molecules, but not necessarily things like co-factors.
- Sample GO-CAM model: http://noctua.geneontology.org/editor/graph/gomodel:5db9c9a500000296