Annotation Conf. Call 2020-01-28

Agenda and Minutes

• Present:

Annotation Relations

• Goal is to review use of relations across annotations (standard and GO-CAM) and the ontology to ensure consistency wherever possible
• Relations to discuss this week:
  • 'activated by'
  • 'activated by' had been used to identify a chemical substance that increases the activity of the gene product.
  • We would like to instead model this with a 'binding activity' that 'directly positively regulates' a second, or main, molecular function enabled by the gene/gene product
  • The aim is to capture regulatory molecules, but not things like co-factors.
  • Sample GO-CAM model: http://noctua.geneontology.org/editor/graph/gomodel:5db9c9a500000296