Happens during
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Definition
Identifies a process during which a biological process occurs
Comment
This relationship can be used in two ways:
- To add a PHASE to the annotation extension field of a biological processes the ONLY relationship to use is ‘happens_during’ (not part_of)
- To add a biological process to the annotation extension field when the role of the gene product in the process is unclear, but occurs during this specific biological process. Consider the use of the relationship part_of if it is known that the process is definitely part of the biological process
Synonym
occurs_during (EXACT)
Child terms
- None.
Scope of use
Domain
BFO:0000007 ! process (Biological Process or Molecular Function)
Range
GO:0008150 ! Biological Process
Annotation Extension Usage Examples
1. A process occurring during cell development
Statement from paper:
In most cell systems that have been examined, the primary signal transduction pathway for BMPs involves phosphorylation of Smad-1 [22]... To determine if BMP-5 initiates similar signaling events in sympathetic neurons, cultured sympathetic neurons grown in the absence of glial cells were treated with BMP-5 for 30 or 60 min then analyzed by Western blotting using Abs specific for total Smad-1 or for phosphorylated Smad-1. Phosphorylation of Smad-1 is evident within 30 min after exposure to BMP-5 (Figure 4A) with significantly increased pSmad-1 levels apparent at 60min. In contrast, treatment with BMP-5 did not alter levels of total Smad-1 (Figure 4B).
Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) |
---|---|---|---|---|
P22003 BMP5 | GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation | PMID:11580864 | IDA | happens_during(GO:0016358 dendrite development) |
2. A process occurring during a cell cycle phase
Statement from paper:
We here show that the mitotic master phosphatase Cdc14 targets Yen1 to the nucleus in early anaphase through the FEAR network. In Figure 2, Yen1 re-localizes back to the nucleus in early anaphase in a Cdc14-dependent manner.
Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) |
---|---|---|---|---|
Q00684 cdc14 | GO:0034504 protein localization to nucleus | PMID:24626187 | happens_during(GO:0000090 mitotic anaphase) |
Using examples to demonstrate Folding_and_Unfolding using the relationship happens_during
2. Cdc14 targets Yen1 to the nucleus in early anaphase, PMID:24626187
Folded/unfolded | DB (Col 2) | Object (Col 3) | GO ID (Col 5) | Reference (Col 6) | Extension (Col 16) | Parent terms for new folded GO term |
---|---|---|---|---|---|---|
Unfolded | Q00684 | cdc14 | GO:0034504 protein localization to nucleus | PMID:24626187 | happens_during(GO:0000090 mitotic anaphase) | |
Folded | Q00684 | cdc14 | New potential GO term protein localisation to nucleus during mitotic anaphase | PMID:24626187 | happens_during GO:0048471 mitotic anaphase |
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