Happens during

Back to Annotation usage examples for each annotation extension relation

Definition

Identifies a process during which a biological process occurs

Comment

This relationship can be used in two ways:

To add a PHASE to the annotation extension field of a biological processes the ONLY relationship to use is ‘happens_during’ (not part_of)
To add a biological process to the annotation extension field when the role of the gene product in the process is unclear, but occurs during this specific biological process. Consider the use of the relationship part_of if it is known that the process is definitely part of the biological process

Synonym

occurs_during (EXACT)

Child terms

None.

Scope of use

Domain

BFO:0000007 ! process (Biological Process or Molecular Function)

Range

GO:0008150 ! Biological Process

Annotation Extension Usage Examples

1. A process occurring during cell development

Statement from paper:

In most cell systems that have been examined, the primary signal transduction pathway for BMPs involves phosphorylation of Smad-1 [22]... To determine if BMP-5 initiates similar signaling events in sympathetic neurons, cultured sympathetic neurons grown in the absence of glial cells were treated with BMP-5 for 30 or 60 min then analyzed by Western blotting using Abs specific for total Smad-1 or for phosphorylated Smad-1. Phosphorylation of Smad-1 is evident within 30 min after exposure to BMP-5 (Figure 4A) with significantly increased pSmad-1 levels apparent at 60min. In contrast, treatment with BMP-5 did not alter levels of total Smad-1 (Figure 4B).

Gene Name (col 2)	GO ID (col 5)	Reference (col 6)	Evidence (col 7)	Annotation Extension (col 16)
P22003 BMP5	GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:11580864	IDA	happens_during(GO:0016358 dendrite development)

2. A process occurring during a cell cycle phase