Annotation Extension Relation:has direct input

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Identifies an entity directly affected (bound, transported, modified, consumed or destroyed) by the gene product's participation in a Molecular Function or Biological Process.


If the entity is indirectly bound/acted upon by the gene product that is the subject of an annotation, then the relation: has_indirect_input should be considered.


directly_localizes NARROW

has_direct_target EXACT

has_substrate NARROW

Child terms

  • None

Scope of use


BFO:0000007 ! process (Biological Process or Molecular Function)


ENTITY_UNION:0000005 ! chemical, gene product, or complex

Annotation Extension Usage Examples

Transcription factor binding to potential target sequences in vitro:

Statement from paper:

By performing gel electrophoretic mobility shift assays, we could detect efficient binding of ATF-2 to the elements found in the bec-1 and lgg-1 promoters (Fig. 5C).

(Note that binding to lin-48 is also reported as a positive control).

Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16)
WBGene00000220 GO:0001012 RNA polymerase II regulatory region DNA binding PMID:21502138 IDA

has_direct_input(WB:WBGene00000247 bec-1)|has_direct_input(WB:WBGene00002980 lgg-1)|has_direct_input(WB:WBGene00003033 lin-48)

Targets of protein kinase activity:

Statement from paper:

A final line of evidence that BAF-1 is a substrate for VRK-1 was obtained with purified recombinant proteins, which demonstrated that BAF-1 was phosphorylated by VRK-1 in vitro (Figure 4H, lower panel). In addition, VRK-1 was autophosphorylated (Figure 4H, upper panel).

Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16)
WBGene00017895 GO:0004672 protein kinase activity PMID:17170708 IDA

has_direct_input(WB:WBGene00000235 baf-1)|has_direct_input(WB:WBGene00017895 vrk-1)

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