Has output: Difference between revisions
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== Using examples to demonstrate [[Folding_and_Unfolding]] using the relationship has_output == | == Using examples to demonstrate [[Folding_and_Unfolding]] using the relationship has_output == | ||
'''1 | '''1. Abnormal G-CSF and chemokine production in G6PT-deficient mice, PMID:12925567''' | ||
{| class="wikitable" border="1" | {| class="wikitable" border="1" | ||
| Line 95: | Line 66: | ||
| MGI:1316650 | | MGI:1316650 | ||
|Putative glycogen storage disease type 1b protein | |Putative glycogen storage disease type 1b protein | ||
|GO:0001816 <span style="color:green">cytokine production</span> | |GO:0001816 <span style="color:green">Granulocyte colony-stimulating factor cytokine production</span> | ||
|PMID:12925567 | |PMID:12925567 | ||
| | | | ||
Revision as of 08:59, 16 June 2014
Definition
Identifies an entity that is changed or created after participation in a molecular function or biological process.
Child terms
- None
Scope of use
Domain
GO:0008150 ! process (Biological Process)
Range
ENTITY_UNION:0000005 ! chemical, gene product, or complex
Annotation Extension Usage Examples
1. Abnormal G-CSF and chemokine production in G6PT-deficient mice
Statement from paper:
The neutropenia and stimulation of myelopoiesis in G6PT−/− mice suggest that G-CSF (20,21) levels might be elevated. During the first 2–3 weeks, when neutropenia is most severe and the elevation in CFU-G is highest, the plasma G-CSF level in G6PT−/− mice is elevated to 17 263±4917 pg/ml, compared with 10±7 pg/ml in the G6PT+/+ or G6PT+/− mice (Fig. 5A). After weaning, with the improvement in neutropenia and decline in overproduction of CFU-G, the plasma G-CSF level in G6PT-deficient mice drops significantly. However, even at 22 weeks of age, the plasma G-CSF in the G6PT−/− mice remains 12-fold higher than age-matched controls (Fig. 5A), suggesting an underlying problem with neutrophil production.
| Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) |
|---|---|---|---|---|
| MGI:1316650 Putative glycogen storage disease type 1b protein | GO:0001816 cytokine production | PMID:12925567 | IMP | has_output(MGI:1339751 Granulocyte colony-stimulating factor) |
Using examples to demonstrate Folding_and_Unfolding using the relationship has_output
1. Abnormal G-CSF and chemokine production in G6PT-deficient mice, PMID:12925567
| Folded/unfolded | DB (Col 2) | Object (Col 3) | GO ID (Col 5) | Reference (Col 6) | Extension (Col 16) | Parent terms for new folded GO term |
|---|---|---|---|---|---|---|
| Unfolded | MGI:1316650 | Putative glycogen storage disease type 1b protein | GO:0001816 cytokine production | PMID:12925567 | has_output (MGI:1339751 Granulocyte colony-stimulating factor) | |
| Folded | MGI:1316650 | Putative glycogen storage disease type 1b protein | GO:0001816 Granulocyte colony-stimulating factor cytokine production | PMID:12925567 | No new GO term created |
Back to Annotation usage examples for each annotation extension relation